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Schizophrenia--neurodevelopmental and neurodegenerative theory revisited

, : Schizophrenia--neurodevelopmental and neurodegenerative theory revisited. Psychiatria Polska 39(2): 249-258

The paper presents a critical review regarding the pathogenesis of schizophrenia. The neurodevelopmental theory which is now mostly recognized, needs some explanations, some elements of neurodegenerative theory are revisited. The developmental factors are confirmed as important in the pathogenesis of schizophrenia, but still it is unclear, how relatively subtle early damage causes so heavy thinking and emotional distortion like schizophrenia. There is also lack of evidence for neurodegeneration. Neuroimaging studies show the evidence for progression of brain abnormalities but at the same time there is no progression in neurocognitive disorders. Most likely late developmental disorders interfere with early brain damage, which leads to a neurocognitive disorder and clinical symptoms of schizophrenia.


PMID: 15881620

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