geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Serotonergic mechanisms in aggression


, : Serotonergic mechanisms in aggression. Novartis Foundation Symposium 268: 171-83; Discussion 183-9, 242-53

The serotonergic system in the CNS has complex interactions with many, if not all other neurotransmitter systems in the brain. Its localization, distribution and amazing receptor diversity makes it an appealing system for modulatory aspects in many basic behaviours, including food and water intake, sexual behaviour and aggression. Notwithstanding decades of research into the putative role of the serotonergic system in aggression, no clear picture about its specific role has emerged. It seems, dependent on state or trait, to be involved in either the performance or the termination of aggressive behaviours. The present technology appears not developed enough to give answers to these questions. Application of drugs and particular selective ligands for certain subtype receptors seems a more promising approach to unravelling the role of 5-HT in aggression. The (postsynaptic) 5-HT1B and to a lesser extent, the 5-HT1A receptor seems to play a prominent role, at least in rodents, in the modulation of (offensive) aggression.

US$29.90

PMID: 16206880


Other references

Nagano M.; Toyoguchi C., 1972: Statistical studies on the thickness of back fat in grading dressed pork carcass. Bulletin of the College of Agriculture & Veterinary Medicine Nihon University (29): 50-57

Puglisi, S.; Lovreglio, R.; Attolico, M., 1999: Subpopulation differentiation along elevational transects within two Italian populations of Scots pine (Pinus sylvestris L.). Two Italian populations of Scots pine (Pinus sylvestris) have been sampled at Morgex (Valle d'Aosta) and Morbegno (Lombardia), along elevational transects at three different altitudes. The genetic structure of the six subpopulations has been...

Cardenas, S., 1978: Sur la presence de Diplodus bellottii (Steindachner, 1882) sur les cotes europeennes. Bulletin de l'Office National des Peches Republique Tunisienne, 21-2: 97-99

Schwarz S.S.; Freed W.J., 1987: Neonatally transplanted brain tissue protects the adult rat from a lesion induced syndrome of adipsia aphagia and akinesia. Azmitia, E C And A Bjorklund (Ed ) Annals Of The New York Academy Of Sciences, Vol 495 Cell And Tissue Transplantation Into The Adult Brain; Conference, New York, New York, Usa, April 2-4, 1986 Xvi+813p The New York Academy Of Sciences: New York, New York, Usa Illus 786-787

Randall, John E., 2001: Revision of the generic classification of the hawkfishes (Cirrhitidae), with descriptions of three new genera. Zootaxa. 7 November; 12: 1-12

Levine, R.L., 1999: Presidential address: A field of dreams. Journal of the American Association of Gynecologic Laparoscopists 6(1): 1-4

Guis, S.; Mattei, J-Pierre.; Cozzone, P.J.; Bendahan, D., 2005: Pathophysiology and clinical presentations of rhabdomyolysis. Rhabdomyolysis has sparked new interest in recent years. The causes of rhabdomyolysis include drugs and other toxic agents, infections, physical exertion, crush injury, and muscle diseases (dystrophinopathies and metabolic myopathies). Prompt iden...

Zhu NaiMiao; X.C.ongJing; Huang JianNan; Liu YanHua; Chen JianHua; Zhang SiZhen, 1995: A comparative study on agriculture development in Beijing, Tianjin and Shanghai. A comparative study on agricultural development in Beijing, Tianjin and Shanghai was conducted. Results were obtained using research data from 1989. Measures and methods of stimulating the construction of a suburb-type modernized agriculture in Sh...

Hosker, R.P.J.; Nappo, C.J.J.; Hanna, S.R., 1974: Diurnal variation of vertical thermal structure in a pine plantation. A brief discussion of results obtained during measurements made in 1972 in a 25-yr-old plantation of loblolly pine [Pinus taeda] near Oak Ridge, Tennessee. The ht. and spacing of the trees were 17 and 3 m respectively. On clear days a very unstabl...

Moore-Dotson, J.M.; Papke, J.B.; Harkins, A.B., 2010: Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown. The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release....