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Splenic lymphoma arising in a patient with Gaucher disease. A case report and review of the literature

, : Splenic lymphoma arising in a patient with Gaucher disease. A case report and review of the literature. Archives of Pathology & Laboratory Medicine 127(5): E242-E245

Patients with Gaucher disease have an increased risk of malignancies, especially the lymphoreticular type. To our knowledge, this is the first reported case of Gaucher disease diagnosed during the workup and diagnosis of a splenic marginal-zone lymphoma with progression to diffuse large B-cell lymphoma. There are several theories as to how Gaucher disease leads to malignancies. The accumulated glucocerebroside in the reticuloendothelial organs, histologically visible as Gaucher cells, is thought to provide chronic antigenic stimulus to the immune system. Polyclonal hypergammaglobulinemia develops, and monoclonal populations of lymphocytes and plasma cells may arise from this premalignant proliferative state. How Gaucher disease is related to nonlymphoid malignancies remains unclear.


PMID: 12708922

DOI: 10.1043/0003-9985(2003)127<e242:SLAIAP>2.0.CO;2

Other references

Esch, H.G.A. van, 1980: Cool radishes against leaf yellowing. Radishes in boxes covered with plastic, or not covered, were placed in a cold store at 3-4 deg C, or held at room temperature, for 0.5, 2 or 3 days. Cooling reduced radish temperatures from 17 deg to 3-4 deg in 5 or 6 h; on removal from the cold s...

Morowitz, H.J., 1984: Ego niches. Hospital Practice 19(8): 185, 189-90

Frisvad, Jens C., 1994: Correspondence, principal coordinate, and redundancy analysis used on mixed chemotaxonomical qualitative and quantitative data. A mixed type data matrix consisting of 11 quantitative carbohydrate variables and 23 binary secondary metabolites data measured in 5–8 isolates of 7 species of Penicillium was analyzed using different multivariate statistical methods. This kind...

Dagorn, J., 1982: Technical management informed on reproduction performances. Levage porcin: (116) 26-31

Baird A.K.; McIntyre D.B.; Welday E.E.; Baird K.W., 1968: Regional chemical variations in batholithic rocks of southern California; progress report. Special Paper Geological Society of America: 8. 1968.

Learner, S., 2011: Happy to be of service. Many NHS nurses volunteer for the St John Ambulance service in their spare time.

Sewell, J., 1999: Position of CVP lines. Anaesthesia 54(6): 617-618

Majewski, A., 1977: Case of tetany in a newborn infant. Wiadomosci Lekarskie 30(23): 1835-1836

Cats, A.; Dullaart, R.P.F.; Zwart, N.; Kleibeuker, J.H.; D.V.ies, E.G.E., 1993: Increased colonic epithelial cell proliferation in acromegalic patients. Proceedings of the American Association for Cancer Research Annual Meeting 34(0): 192

Benham, W.D., 1896: Earthworms and Streamworms: review of Beddard's monograph on the Oligochoeta. Nature, liii 74 & 75