+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synovial sarcoma (SS): new perspectives supported by modern technology

, : Synovial sarcoma (SS): new perspectives supported by modern technology. Arkhiv Patologii 64(3): 39-47

Based upon the experience of 256 cases of synovial sarcoma (SS), the present review analyzes structural, biological and molecular pathology of this poorly known sarcoma. The histology displays a multiphenotype with two major components: biphasic and monophasic SS. In addition, a number of variants have been described: undifferentiated Ewing's like, myoxid and predominantly epithelial (monophasic epithelial sarcoma). Microcalcifications and squamous metaplasia are often seen in the tumor. Immunohistochemistry with EMA and cytokeratin in the epithelial or epithelioid component is diagnostic for SS together with vimentin positivity in the spindle cells. Several other epitopes are also expressed (CD99, CD56, C-MET, HGF/SF, CD44). The ultrastructure confirms the variegated pattern of the neoplasm demonstrating the epithelial component and the epithelioid or spindle cell type closely associated with each other. Transition of epithelial cells to epithelioid and spindle-like mesenchymal component is seen. Nude-mice xenografts and cell lines after in vitro culture confirm heterogeneity of this sarcoma. Molecular histology of the SS has provided high utility not only for their differential diagnosis due to a specific chromosomal translocation: t(X;18)(p11.2;q11.2) but also after cloning these breakpoints resulting in the fusion of two genes: SYT at 18q11 and SSX at Xp11. Further observations have lead to distinguish the existence of two related genes: SSX1 and SSX2, that provide a highly specific and sensitive diagnostic marker for SS. Moreover, clinical correlations have demonstrated that SYT-SSX1 leads to a poor clinical outcome while the fusion SYT-SSX2 provides survival advantages to the patients.


PMID: 15338724

Other references

Mezev-Krichfalushii, H.M., 1987: Seed productivity of ornithogalum umbellatum l. liliaceae in the transcarpathian oblast ukrainian ssr ussr. Results obtained from studies of seed producitivity in three populations of Ornithogalum umbellatum L. in the Transcarpathian territory are presented. It is noted that there is a difference between the elements of generative reproduction of O. umb...

Ibric Cioranu, V.; Iorgulescu, D.; Petrescu Seceleanu, V.; Ibric Cioranu, S.; Toma, C.; Fronie, A.Ioan.; Făgeţan, I.Mihai.; Nicolae, V., 2015: Malignant ameloblastoma in an 8-year-old child with metastasis to the lung: case report with a clinicopathologic analysis. Ameloblastomas are rare tumors of odontogenic origin, accounting for 1% of all oral tumors. They are benign, but locally highly aggressive tumors. We report here the unusual case of an 8-year-old patient with multicystic mandibular ameloblastoma,...

Rivolta, D.; Palermo, R.; Schmalzl, L.; Williams, M.A., 2012: Investigating the features of the m170 in congenital prosopagnosia. Face perception generates specific neural activity as early as 170 ms post-stimulus onset, termed the M170 when measured with Magnetoencephalography (MEG). We examined the M170 in six people with congenital prosopagnosia (CP) and 11 typical cont...

Hutchings, P.A.; Smith, R.I., 1997: Descriptions of new species and comments on previously described species of terebellid polychaetes from New Zealand and Australia. One new genus (Pseudopista) and six new species (Streblosoma toddae, Thelepus australiensis, Neoleprea papilla; Nicolea armilla, Pista pegma, and Pseudopista rostrata) of Terebellidae are described from New Zealand and Australia. Terebella plagios...

Mikulenko K.I.; Sitnikov V.S., 1993: Geology and oil-gas potential of the overthrust belts of West Yakutia. Petroleum Geology 27(11-12): 394-398

Lewis-Jones, D.I.; Aird, I.A.; Biljan, M.M.; Kingsland, C.R., 1996: Effects of sperm activity on zinc and fructose concentrations in seminal plasma. Attempts to correlate zinc and fructose concentrations in seminal plasma with andrological parameters have produced inconsistent results. To assess further this relationship, a prospective study was performed measuring zinc and fructose concentrat...

Yarze, J.C.; Schupp, S.L.; Fritz, H.P.; Lusignan, D.N., 2000: Hemorrhage related to an anal dieulafoy-like lesion. American Journal of Gastroenterology 95(6): 1593-1594

George, J.C.; Shah, R.V., 1954: The occurrence of a straited outer muscular sheath in the lungs of Lissemys punctata granosa Schoepff. A muscle covering composed of striated muscles enveloping the lungs occurs in Lissemys punctata granosa. Another muscle covering occurs outside the one mentioned above. This envelopes in addition to the lungs most of the visceral organs. When one...

Perez, M.V.; Friday, K.; Froelicher, V., 2012: Semantic confusion: the case of early repolarization and the J point. American Journal of Medicine 125(9): 843-844

Lemire, M.; Deloince, R.; Grenot, C., 1972: Histoenzymological study of the "salt" gland of the Sahara lizard, Uromastix acanthinurus Bell. Comptes Rendus Hebdomadaires des Seances de L'academie des Sciences. Serie D: Sciences Naturelles 274(25): 3413-3416