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Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

, : Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41. Chemical Communications: 2552-2554

We present a straightforward and high yielding method to synthesize constrained helical peptides via thioether ligation; this method represents an attractive alternative to the formation of lactam bridge constraints to induce helicity in peptides.


PMID: 15900323

DOI: 10.1039/b419015g

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