geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The ATPases: a new family for a family-based drug design approach


, : The ATPases: a new family for a family-based drug design approach. Expert Opinion on Therapeutic Targets 7(3): 453-461

The rapid discovery of new drugs is greatly facilitated when a family of related proteins is targeted with a similar approach in chemistry. Few protein families have so far been investigated using this kind of 'family-based' approach. Therefore, to increase the size of our Pharmacopeia and to cure human diseases more efficiently, new druggable protein families must be identified. It is shown in this review that ATPases are very good candidates for a family-based approach. The human proteome contains many ATPases, which are involved in several diseases. All the ATPases contain a nucleotide-binding site, and it is therefore possible to target all of them with a single strategy in chemistry; the design of competitive ATP inhibitors. Moreover, because a similar approach has been conducted with the protein kinases, the compound libraries and the knowledge developed in the kinase field can be directly applied to the ATPases.

US$19.90

PMID: 12783580

DOI: 10.1517/14728222.7.3.453


Other references

Attah, P.; Van-Emden, H., 1993: The susceptibility to malathion of Metopolophium dirhodum on two wheat species at two growth stages, and the effect of plant growth regulators on this susceptibility. Malathion tolerance of the rose-grain aphid Metopolophium dirhodum (Walker) reared on the ancient wheat variety Emmer (Triticum dicoccum L.) was tested by topical bioassay and found to be lower than that of aphids reared on the modern more suscept...

Amachika, T.; Kobayashi, D.; Moriai, R.; Tsuji, N.; Watanabe, N., 2007: Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. There have been no target molecules that have enabled us to diagnose lung cancer with high sensitivity and specificity even in its early clinical stages. A molecule termed novel oncogene with kinase-domain (NOK) was recently reported as a receptor...

Courbier, R.; Baille, Y.; Jausseran, J.; Gros, M.; Henry, E., 1974: Causes of failure of aorto-coronary saphenous vein bypass. Journal of Cardiovascular Surgery 15(2): 146-148

Graham-Smith, G.S., 1919: Further Observations on the Habits and Parasites of Common flies. The habit of cleansing themselves exhibited by flies and the influence of weather upon them is discussed. With regard to the latter, experiments show that the curve indicating the number of flies caught corresponds with that for the maximum temper...

Saurio, L., 1948: Study of severe cases of chicken pox. Duodecim; Laaketieteellinen Aikakauskirja 64(8-9): 685-696

Blane, D., 2004: In WHO's interest: the debate surrounding the 2003 election of the Director-General of WHO. Lancet 364(9440): 1188-1189

Verma, S.; Pant, N.C., 1976: Effect of temperature on the dissipation of phorate in soil. Soil kept at 15, 30 or 45 deg C for 24 h before treatment with phorate at 1.5 kg toxicant/ha was then returned to these temperatures, and samples taken at intervals after treatment were analysed for residues by bioassay with Drosophila melanogaste...

Colosimo, C.; Moschini, M.; Rollo, M.; Tartaglione, T., 1993: Brain stem gliomas. Rays 18(4): 541-562

L.Y.nhe; Wan Defang; Jiang Shaoyong; Zhong Hua, 1995: Silicon isotope study on the Meishucun Precambrian-Cambrian boundary section, Yunnan. Dizhi Lunping = Geological Review 41(2): 179-187

Zhang K.; Chiang L.C.; Ueng P.; Tsao G.T., 1982: Production of yeast single cell protein from bagasse hemi cellulose hydrolysate and its alcohol fermented waste liquor. Abstracts of the Annual Meeting of the American Society for Microbiology 82: ABSTRACT O11