geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The La protein-RNA complex surfaces


, : The La protein-RNA complex surfaces. Molecular Cell 21(2): 149-152

A recent issue of Molecular Cell reported that the typical nucleic acid binding surfaces of the RRM and winged-helix motifs, although present in the RNA binding protein La, are not used to engage its best-characterized ligand, 3' UUU-OH. Instead, La uses edgewise and backsides of these motifs for UUU-OH recognition, leaving open their typical surfaces for other potential interactions. These observations provide a framework for appreciating the various activities attributed to this ubiquitous nuclear phosphoprotein, which include its principal function, snRNA 3' end protection, in addition to mRNA-related and RNA chaperone-like activities, as well as DNA and chromatin-associated activity.

US$19.90

PMID: 16427005

DOI: 10.1016/j.molcel.2006.01.004


Other references

Whatley S.A.; Hall C.; Menzies D.E.; Lim L., 1981: Chromatin organization in the hypothalamus during development. Biochemical Society Transactions 9(2): 128P

Ursinus, A.; Steinhaus, H.; Höltje, J.V., 1992: Purification of a nocardicin A-sensitive LD-carboxypeptidase from Escherichia coli by affinity chromatography. An LD-carboxypeptidase releasing the terminal D-Ala from UDP-MurNAc-L-Ala-D-Glu-m-A2pm-D-Ala (UDP-MurNAc-tetrapeptide) was purified from Escherichia coli to biochemical homogeneity and characterized biochemically. Final purification was achieved b...

Kennedy, T.J.; Chan, C-Yip.; Ding, X-Zhong.; Adrian, T.E., 2003: Lipoxygenase inhibitors for the treatment of pancreatic cancer. Pancreatic cancer has a dismal prognosis with no effective medical therapy. Therefore, there is a need to search for novel targets for cancer prevention and treatment. The lipoxygenases oxygenate arachidonic acid and other 20-carbon fatty acids an...

Ikeda, K.; Morizono, T., 1989: Effects of carbon dioxide in the middle ear cavity upon the cochlear potentials and cochlear pH. To elucidate the effects of CO2 in the middle ear upon the cochlea, measurements were made of the cochlear potentials (compound action potential and endocochlear potential) and of the pH of the inner ear fluids and the organ of Corti. Gas containi...

Adam, S.; Champion, H.; Daly, A.; Dawson, S.; Dixon, M.; Dunlop, C.; Eardley, J.; Evans, S.; Ferguson, C.; Jankowski, C.; Lowry, S.; MacDonald, A.; Maritz, C.; Micciche, A.; Robertson, L.; Stafford, J.; Terry, A.; Thom, R.; van Wyk, K.; Webster, D.; White, F.J.; Wildgoose, J., 2012: Dietary management of urea cycle disorders: UK practice. There is no published data describing UK dietary management of urea cycle disorders (UCD). The present study describes dietary practices in UK inherited metabolic disorder (IMD) centres. Cross-sectional data from 16 IMD centres were collected by a...

Yamamoto, T.H.; Mével-Ninio, M.; Valentine, R.C., 1973: Essential role of membrane ATPase or coupling factor for anaerobic growth and anaerobic active transport in Escherichia coli. Mutants of Escherichia coli defective in coupling electron transport to synthesis of ATP (unc) were isolated and screened for Mg2+-ATPase activity using a rapid and sensitive Millipore filtration assay. An episome (F16) carrying ATPase genes was u...

Benoliel, R.; Zadik, Y.; Eliav, E.; Sharav, Y., 2012: Peripheral painful traumatic trigeminal neuropathy: clinical features in 91 cases and proposal of novel diagnostic criteria. To field-test carefully designed criteria for pain following trigeminal nerve trauma. In order to characterize the clinical phenotype, posttraumatic pain patients were studied and compared with classical trigeminal neuralgia patients (CTN, defined...

Forgays, D.G., 1986: Personality characteristics and self-abusive behavior. Nida Research Monograph 74: 45-58

Keech R.V.; Scott W.E.; Baker J.D., 1990: The medial rectus muscle insertion site in infantile esotropia. The distance from the corneoscleral limbus to the insertion site of the medial rectus muscle was measured at several stages of medial rectus recession surgery in 20 patients (40 eyes) with infantile esotropia. Disinsertion of the medial rectus mus...

Strohecker, H.F., 1937: A survey of soil temperatures in the Chicago area. Thermometer and thermograph measurements of soil temp?, in the sand dunes showed maximum temps. (64[degree]C.) approximating" those reported for deserts. The maxima in the stages of forest growth decrease in the order of ecological succession...