geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia


, : The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia. Pharmacogenetics 13(9): 577-580

The 870A>G polymorphism in the cyclin D1 (CCND1) gene modulates mRNA splicing, leading to altered protein that may affect the regulation of the G1/S cell-cycle checkpoint. This polymorphism has been reported to influence susceptibility to and progression of several malignancies. Furthermore, the change of retinoblastoma protein regulation mediated by CCND1 may play a role in the development of methotrexate (MTX) resistance via an associated higher activity of enzymes that are inhibited by MTX. This study shows that children with acute lymphoblastic leukaemia (ALL) who are homozygous for the CCND1 A variant have a lower probability of event-free survival (P = 0.006) compared to carriers of the G variant. A significant result is retained in the presence of other prognostic factors. This impact is even more apparent in individuals who are also homozygous for thymidylate synthase (TS) triple repeat (P < 0.00005), which has previously been shown to influence the outcome of childhood ALL.

US$19.90

PMID: 12972956

DOI: 10.1097/01.fpc.0000054123.14659.57


Other references

Ferrer Marrades, J.; Goday Arnó, A.; Esmatjes Mompó, E., 1990: The perception of hypoglycemia with human insulin. Medicina Clinica 95(20): 790-792

Desmedt, J.E., 1984: Clinical uses of evoked potentials. Rinsho Shinkeigaku 24(12): 1198-1210

Sachsenweger, R., 1956: Effects of heterophoria on space perception. Das Deutsche Gesundheitswesen 11(26): 883-890

Webster T.A.; Lathrop R.H.; Smith T.F., 1987: Prediction of a common structural domain in aminoacyl transfer rna synthetases through use of a new pattern directed inference system. The aminoacyl-tRNA synthetases are united by a common function with little evidence of a common structural relationship. Outside of an 11 amino acid stretch called the "signature sequence", no global primary sequence similarity exists. T...

Yang, Yu; Yang, Xin; Yang, Hai-Feng; Liu, Zhi-Min; Liu, Yan-Li; Shen, Guo-Li; Yu, Ru-Qin, 2005: Electrochemical sensor for cinchonine based on a competitive host-guest complexation. An electrochemical sensor for cinchonine (CCN) using the beta-cyclodextrin (beta-CD) modified poly(N-acetylaniline) (PAA) electrode has been developed, in which 1,4-hydroquinone (HQ) was chosen as a probe. Complexation of HQ with beta-CD modified...

Garg, F.C.; Beri, N.; Tauro, P., 1982: Nodular nitrogenase activity during various growth phases of cowpea (Vigna unguiculata). In cowpea plants grown in a N-free medium in jars at 47.5 degrees C, nitrogenase activity increased up to 4 wk after sowing while nodule wt. continued to increase up to the 8th wk.

Choi, Y.H.; Kim, J.W.; Kim, D.K.; Rhee, C.H.; Lee, W.R., 1997: Angiotensin-converting enzyme gene polymorphism is associated with chronic HBV infection A possible link to human longevity. Journal of the American Geriatrics Society 45(9): S63

Sperlongano, P.; Pisaniello, D.; D.M.uro, U.; Pone, D.; Casoli, E., 2000: Management of testicular seminoma. Our experience. The authors report their experience in the management of seminomas. They examine 12 cases of seminoma among a series of 19 patients with testicular germ cell tumours observed at the Second Surgical Department of the Second University of Naples. Th...

Froment, R.; Galiavardin, L.; Cahen, P., 1951: Attrition and vibrations in constrictive pericarditis. Imprensa Medica 27(445): 29-32

García-Silva, Jús.; Almagro, M.; Peña-Penabad, C.; Fonseca, E., 2002: Indinavir-induced retinoid-like effects: incidence, clinical features and management. Since 1998, many cases of antiretroviral therapy-related paronychia of the toes or fingers and ingrown toenails have been reported. Most of them were related to indinavir. Other indinavir-induced mucocutaneous disorders resembling the adverse effe...