geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection


, : The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology 118(4): 520-526

Mice deficient in RNA-dependent protein kinase (PKR-/-) or deficient in PKR and a functional 2',5'-oligoadenylate synthetase (OAS) pathway (PKR/RL-/-) are more susceptible to genital herpes simplex virus type 2 (HSV-2) infection than wild-type mice or mice that are deficient only in a functional OAS pathway (RL-/-) as measured by survival over 30 days. The increase in susceptibility correlated with an increase in virus titre recovered from vaginal tissue or brainstem of infected mice during acute infection. There was also an increase in CD45+ cells and CD8+ T cells residing in the central nervous system of HSV-2-infected PKR/RL-/- mice in comparison with RL-/- or wild-type control animals. In contrast, there was a reduction in the HSV-specific CD8+ T cells within the draining lymph node of the PKR/RL-/- mice. Collectively, activation of PKR, but not of OAS, contributes significantly to the local control and spread of HSV-2 following genital infection.

US$19.90

PMID: 16895559

DOI: 10.1111/j.1365-2567.2006.02403.x


Other references

Gray, P.H., 1943: Staining Bacterial Capsules. A modification of Muir's method is descr., which consistently gives good results, and yields more well-defined capsules than the original method.[long dash]Prepare light suspensions in tap water, and allow a loopful to dry on a well-roasted c...

Haas, T., 1999: Control of pain with the help of the infusion apparatus, Infusor. A simple infusion system, the Infusor, described as an elastometric infusion pump, which can be used for continuous administration of drugs, is described with particular reference to the use of opiate analgesics in small animals. A small reservoir...

Shigemasa, K.; Underwood, L.J.; Beard, J.; Tanimoto, H.; Ohama, K.; Parmley, T.H.; O'Brien, T.J., 2000: Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells. In a continued effort to identify and characterize secreted proteases that are overexpressed in ovarian carcinomas, we discovered the testisin protease as such a candidate. When this discovery was originally made, no data existed in the literature...

Salzmann, M.; Seidel, K.N.; Bernard, Ré.; Prüss, H.; Veh, Rüdiger.W.; Derst, C., 2011: BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons. Large conductance Ca(2+)-activated BK channels are important regulators of action potential duration and firing frequency in many neurons. As the pore-forming subunits of BK channels are encoded by a single gene, channel diversity is mainly genera...

Barlow, R.M.; McGorum, B., 1985: Ovine listerial encephalitis: analysis, hypothesis and synthesis. Analysis of field reports suggested that listerial encephalitis in sheep was most common in winter and early spring in the age groups of sheep which would be cutting, changing and possibly losing teeth. It was hypothesized that, under these condit...

DeLong, K.A.; Kutas, M., 2016: Hemispheric differences and similarities in comprehending more and less predictable sentences. NlmCategory="UNASSIGNED">With a growing literature demonstrating the predictive nature of language processing, the current study examines contributions of the brain's two hemispheres in processing more and less probable sentence...

Zhou, X-han.; Li, M-gui.; Lü, X-hong.; Wu, X-yue.; Yu, J-ping., 2006: Effect of rosiglitazone on metalloproteinase tissue inhibitor-1 in CCl4-induced liver fibrosis in rats. Zhonghua Gan Zang Bing Za Zhi 14(9): 703-704

Leonard, B.J., 2001: Quality nursing care celebrates diversity. At the beginning of the 21st century, the familiar biomedical health care "culture" must accommodate not only persons from diverse cultures, but also diverse systems of care. For perhaps the first time in over a century, biomedicine must...

Fogg Graham E.; Noyes Charles D.; Carle Steven F., 1998: Geologically based model of heterogeneous hydraulic conductivity in an alluvial setting. Information on sediment texture and spatial continuity are inherent to sedimentary depositional facies descriptions, which are therefore potentially good predictors of spatially varying hydraulic conductivity (K). Analysis of complex alluvial hete...

Nagy, L.; Nagy, J.; Legg, C., J.; Sales, D., I.; Horsfield, D., 2002: Monitoring vegetation change caused by trampling: A study in the Cairngorms, Scotland. A study was made in the Cairngorms, Scotland to make recommendations for a monitoring scheme capable of detecting changes in the vegetation caused by recreational pressure following the development of a funicular railway. Four methods were used in...