+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?

, : The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?. Clinical Advances in Hematology & Oncology 2(7): 441-446

The goal of eliminating the low levels of infectious disease risk from hemophilia treatment has resulted in the development of multiple generations of recombinant factor VIII (rFVIII) products. The ideal product should be devoid of human and animal proteins, which may transmit infectious agents. These products should also maintain molecular integrity, hemostatic efficacy, similar immunogenicity, and acceptable side effect profiles as compared to plasma-derived factor VIII. Currently available first-, second-, and third-generation rFVIII products include Recombinate; Kogenate FS/Helixate FS and ReFacto; and Advate, respectively. During the evolution of rFVIII products, either full-length or B-domain-deleted factor VIII were transfected into immortalized cell lines. The B-domain-deleted product, ReFacto, has resulted in an additional method to monitor factor VIII levels. The third-generation products offer the theoretical advantage of being produced without human and/or animal proteins. Upon initial introduction into the marketplace, the newer products have a higher cost. However, when analyzing historical trends, the prices of these products are almost equivalent to first-generation products within 3 years of licensure. Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy.


PMID: 16163220

Other references

Sgarbi, E.; Esposito, B.; Parmiani, M., 1965: Splenic Rupture Due To Closed Trauma Of The Abdomen. L' Arcispedale S. Anna di Ferrara 18: 399-425

Spaeth, E.; Rüde, E., 1985: Development of T cell clones reactive to two defined restriction elements in conjunction with two defined epitopes of antigen. A previously described pig insulin (PI)-specific T cell line of (B10 .times. B10.BR)F1 origin was assayed for its reactivity with species variants of insulin in the presence of antigen-presenting cells (APC) of various H-2 haplotypes. In addition...

L.H.iChen; Chang ChyanHsing; Wang HsiuFen; Cheng ChihKai, 1998: Changes of body composition and liver function in rats with continuous and cyclic parenteral nutrition. It has been suggested that cyclic infusion of total parenteral nutrition (TPN) solution can prevent the hepatobiliary complications induced by continuous infusion. The aim of this study was to investigate the effects of cyclic infusion of TPN solu...

Kaimowitz, D.; Byron, N.; Sunderlin, W., 1998: Public policies to reduce inappropriate tropical deforestation. The ways and extent to which public policy measures might be used to reduce inappropriate tropical deforestation are investigated. The central thesis of the paper is that individuals and businesses deforest because it is their most profitable alte...

Pratt, I., 1941: The Effect of Eimeria tenella (Coccidia) Upon the Glycogen Stores of the Chicken. Earlier work by P. showed that the blood sugar of the chicken was markedly increased during the acute stages of caecal coccidiosis. As this increase occurred when the birds were feeding continuously, as well as when they were starved for 19 hours,...

Guzey, M.; Vural, H.; Satici, A., 2002: Endothelin-1 increase in aqueous humour caused by frequency-doubled Nd:YAG laser trabeculoplasty in rabbits. Purpose: To study the effect of Nd:YAG laser trabeculoplasty (LT) on endothelin-1 (ET-1) concentration of aqueous humour and intraocular pressure (IOP) in rabbits. Methods: One eye of each of 18 pigmented rabbits was subjected to 360degree LT with...

Lee L.S., 1980: Inhibition of epidermal growth factor binding by phorbol esters saccharin and cyclamate. Cancer Detection & Prevention 3(1)

Deane, N., 1959: Practical physiologic therapy in metabolic and electrolyte imbalances. Postgraduate Medicine 26: 588-597

Noda, S.; Iwakawa, M.; Ohta, T.; Iwata, M.; Yang, M.; Goto, M.; Tanaka, H.; Harada, Y.; Imai, T., 2005: Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice. Aim: To gain insights into inter-strain differences in radiosensitivity. Methods: Mice of inbred strains, A/J, C57BL/6J, and C3H/HeMs, were irradiated at graded doses ranging from 20 to 60 Gy. Skin reaction and leg contraction were observed for a...

Chen, X.; Chen, Z.; Gao, S.; Gao, X., 2014: Brain-computer interface based on intermodulation frequency. Most recent steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems have used a single frequency for each target, so that a large number of targets require a large number of stimulus frequencies and therefore a wi...