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The use of immunohistochemistry in the differential diagnosis of thyroid gland tumors with follicular growth pattern


, : The use of immunohistochemistry in the differential diagnosis of thyroid gland tumors with follicular growth pattern. Ceskoslovenska Patologie 42(3): 120-124

The aim of the study was to evaluate the expression of galectin-3 (gal3), cytokeratin 19 (CK19), neural cell adhesion molecule (NCAM), and E-cadherin (Ecad) in thyroid gland tumors with follicular growth pattern with particular focus on their use in differential diagnosis. A series of 139 cases - 87 follicular adenomas (FAs), 26 follicular carcinomas (FCs), and 26 cases of the follicular variant of papillary carcinoma (FVPC) was studied. Expression of gal3 was found in 29/87 (33%) of FAs, in 13/26 (50%) of FCs, and in 24/26 (92%) of FVPCs. Expression of CK19 was found in 11/87 (13%) of FAs, in 4/26 (15%) of FCs, and in 17/26 (65%) of FVPCs. Expression of NCAM was found in 60/87 (69%) of FAs, in 20/26 (77%) of FCs, and in 7/26 (27%) FVPCs. Expression of Ecad was found in 81/87 (93%) of FAs, in 22/26 (85%) of FCs, and in 17/26 (65%) of FVPCs. The sensitivity and specificity of gal3 for malignancy were 0.70 and 0.85, of CK19 0.48 and 0.98, of NCAM 0.28 and 0.47, and of Ecad 0.48 and 0.20, respectively. A significant difference (p < 0.05) in expression of all studied markers between FVPC versus FA and FC was found, in contrast to FA and FC. Therefore, the use of gal3 and CK19 in differential diagnosis of FVPC versus FA and FC can be recommended.

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PMID: 16955558


Other references

Henney, MR.; Alexopoulos, CJ.; Scheetz, RW., 1980: Didymium atrichum, a new myxomycete from south-central Texas. D. atrichum M.R. Henney and Alexopoulos is described from south-central Texas. Because of the presence of crystalline lime on its peridium, the organism is placed in the genus Didymium, despite its lack of capillitium. The sporangia are produced e...

Kubota, T.K.tatani, H., 1969: The structure of platycodigenin, a 4,4-di (hydroxy-methyl)triterpene. Journal of the Chemical Society: 5 190-191

Garrido, M.J.; Uzcategui, R.C. de, 2000: First report of sugarcane mosaic potyvirus strain D in sugarcane in Venezuela. In an experimental plot of sugarcane (Saccharum spp.) cultivar C5-71 in Maracay, Aragua state, infected plants showed severe symptoms of mosaic viral disease. The disease was mechanically transmitted to some differential hosts for its identificati...

Lal, S.; Dell'Elce, J.; Malla, A.K., 2016: Technology Access and Use Among Young Adults With a First Episode of Psychosis. Psychiatric Services 66(7): 764-765

Wintermantel, E., 1979: A new gearing approximator for microsurgical vascular anastomoses. A new gearing approximator for microsurgical vascular anastomoses is described. A highly precise and smoothly working robust gearing in connection with an asymmetrically notched key allows quick application of the approximator and an exactly adjus...

Hsu, S-Chien.; Chang, S-Shin.; Lee, M-Tse.Gabriel.; Lee, S-Huei.; Tsai, Y-Wen.; Lin, S-Che.; Chen, S-Ta.; Weng, Y-Chieh.; Porta, L.; Wu, J-Yih.; Lee, C-Chang., 2017: Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort. Fluoroquinolone is a commonly prescribed antimicrobial agent, and up to 20% of its users registers adverse gastroenterological symptoms. We aimed to evaluate the association between use of fluoroquinolone and gastrointestinal tract perforation. We...

Tams, S.; Thatcher, J.; Grover, V.; Pak, R., 2016: Selective attention as a protagonist in contemporary workplace stress: implications for the interruption age. The ubiquity of instant messages and email notifications in contemporary work environments has opened a Pandora's Box. This box is filled with countless interruptions coming from laptops, smartphones, and other devices, all of which constantl...

Kelly, M.L.; Murtagh, J.; McCarty, W.C., 1968: Reduplication of the esophagus presenting as mideosophageal web and diverticulum. JAMA 204(1): 73-75

Ozaita, G.; Calandre, L.; Peinado, E.; Rodríguez-Antigüedad, A.; Bermejo, F., 1987: Hematocrit and clinical outcome in acute cerebral infarction. Hematocrits of 131 cerebral infarction cases were correlated with the outcome at 2 weeks. Bivariate analysis showed that cases with more intense admission deficit had lower admission hematocrit and that cases with poorer outcome had lower Day 2 an...

Constantinescu, E.; Safciuc, F.; Sima, A.V., 2012: A hyperlipidemic diet induces structural changes in cerebral blood vessels. The cerebrovascular pathology is an important contributor to the death rate presently. Hyperlipidemia , an established risk factor for cardiovascular diseases, is also incriminated in the neurodegenerative disorders. The aim of this study was to e...