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Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging


, : Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging. Nuclear Medicine Communications 27(12): 933-937

Functional pre-synaptic dopamine brain imaging is generally abnormal when parkinsonism is degenerative (such as in idiopathic Parkinson's disease) and normal in patients with non-degenerative movement disorder (such as essential tremor). However, some patients diagnosed as early Parkinson's disease have normal presynaptic dopamine imaging. Follow-up of patients with normal imaging should help determine whether such patients truly have degenerative parkinsonism (and therefore represent false negative imaging results), or emerge as cases of non-degenerative parkinsonism (and therefore represent initial clinical over-diagnosis of Parkinson's disease). One hundred and fifty cases with normal I-FP-CIT SPECT undertaken during routine care over a 3-year period were reviewed 2.4 years (interquartile range, 2.2-3.1 years) after SPECT. Diagnosis after follow-up was non-degenerative parkinsonism or tremor in 146 (97%), who did not progress clinically, and degenerative parkinsonism in four (3%), in whom clinical progression was noted. Anti-Parkinson therapy was used in 36, and withdrawn in 27 with no deterioration in 25. Patients strictly fulfilling Brain Bank criteria (part 1) were more likely to undergo a trial of anti-Parkinson therapy (P < 0.05) but were no more likely to maintain or respond to anti-Parkinson therapy than those not fulfilling criteria. The clinical profile and therapy response during follow-up of patients with normal presynaptic dopamine imaging supports the diagnosis of a non-degenerative movement disorder in nearly all cases.

US$19.90

PMID: 17088677

DOI: 10.1097/01.mnm.0000243374.11260.5b


Other references

Lin Shoufa, 1991: The geometrical relationship between the stretching lineation and the movement direction of the shear zone. Program with Abstracts - Geological Association of Canada(Mineralogical Association of Canada(Canadian Geophysical Union, Joint Annual Meeting 16: 75

Rutter, A., 2014: A fresh approach is needed to help smokers who want to quit. Nursing Standard 1987) 28(14): 34-34

Gagné, A-M.; Lavoie, J.; Lavoie, M-P.; Sasseville, A.; Charron, M-C.; Hébert, M., 2011: Assessing the impact of non-dilating the eye on full-field electroretinogram and standard flash response. We investigated the possibility of performing electroretinography (ERG) in non-pharmacologically dilated eyes using brighter flash (time-integrated) luminance. Photopic (N = 26; background 25.5 cd·m(-2), white LED flashes) and scotopic ERG (N...

Laukova, A.; Czikkova, S.; Burdova, O., 1999: Anti-staphylococcal effect of enterocin in Sunar(R) and yogurt. Enterocin was used to control the growth of Staphylococcus aureus strains SA1 and Oxford 209P in Sunar(R) (milk nourishment for suckling babies) and during the yogurt-making process. Reduction by three orders of magnitude was noted in the growth o...

Allain P., 1987: Pharmacokinetics and efficacy of hydroquinidine in a prolonged action form in patients suffering from ventricular extrasystoles. Annales De Cardiologie Et D'Angeiologie: 163-166

Ansell, B.J., 2008: Hyperlipidaemia and cardiovascular disease. Current Opinion in Lipidology 19(4): 433-434

Scott, T.R.D.; Bennet, M.R., 1993: The effect of ions and second messengers on long-term potentiation of chemical transmission in avian ciliary ganglia. 1 The effects of tetanic stimulation of the oculomotor nerve on transmission through the avian ciliary ganglion have been determined by use of the amplitude of the compound action potential recorded in the ciliary nerve, in the presence of hexamet...

Beaty David W., 1988: Stratigraphy of the Leadville Dolomite. Professional Contributions of the Colorado School of Mines 12: 109-111

Cooke, D.G.dley, M., 1992: Loss of crystalline and molecular order during starch gelatinisation: origin of the enthalpic transition. The disruption of molecular orders which occur during the gelatinisation of starch granules has been studied by isolating dried samples from maize, waxy maize, wheat, potato, and tapioca starches after defined thermal pre-treatments. Residual mole...

Stief, C.; Kuthe, A.; Uckert, S.; Becker, A.; Jonas, U., 2001: Membrane-bound guanylyl cyclases in human corpus cavernosum Expression and functional relevance. Journal of Urology 165(5 Supplement): 223, May