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Using epidemiology and archaeology to unearth new drug targets for rheumatoid arthritis therapy


, : Using epidemiology and archaeology to unearth new drug targets for rheumatoid arthritis therapy. Drug Discovery Today 11(1-2): 4-7

Epidemiological and archaeological evidence suggests that RA could be a consequence of enhanced immunity to Mycobacterium tuberculosis, and that by understanding this connection, new RA drug targets may be uncovered.

US$19.90

PMID: 16478685

DOI: 10.1016/S1359-6446(05)03627-5


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Wells, S.Steelman., 2012: Rape aggression defense and workplace violence prevention. An R.A.D. Basic Physical Defense program for women employees, launched by a health system's corporate security department, has proven to be a popular low cost method of workplace violence prevention, according to the author, one of the progra...

McCARTY.R.T., 1953: The genetic factor of familial disseminated polyposis coli. American Journal of Surgery 86(5): 500-504

Nguyen, H.Vinh.Lam.; Kannengießer, R.; Stahl, W., 2012: Microwave survey of the conformational landscape exhibited by the propeller molecule triethyl amine. Conformational studies with quantum chemical methods yielded for the most stable conformer of triethyl amine a propeller-like structure belonging to the point group C(3), which corresponds to an oblate top. The microwave spectrum of this conformer...

Haseman, L., 1923: Amount of Arsenic placed in Calyx Cups and Lethal Dosage for Apple Worm. As a result of the experiments described, it has been possible to determine the average arsenical content of the calyx cup of each apple on trees treated with different pressures and nozzles. A high pressure and coarse nozzle were found to be less...

Grechko, V.E.; Puzin, M.N.; Stepanchenko, A.V.; Sineva, N.A.; Kushlinskiĭ, N.E.; Balashov, K.E.; Maksimovskiĭ, I.M.; Bragin, E.O., 1990: Diagnosis and treatment of neurostomatological diseases and syndromes. Basing on clinical and paraclinical findings on 6599 cases of neurostomatological diseases, new pathogenetic schemes of the treatment are proposed.

Tian, T.; Zhao, L.; Zhao, X.; Zhang, M.; Meng, A., 2010: A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b. Foxj1 has been found to play an important role in cilia formation and function in vertebrates. The zebrafish or Xenopus genome expresses two Foxj1 genes, foxj1a/FoxJ1 and foxj1b/FoxJ1.2. In this study, we have generated a zebrafish transgenic line...

Hogue, E.E., 1989: Implications of certification--legal considerations. With certification of specialty nurses here to stay, nurses and certifying organizations must understand several legal issues associated with the process.

Asako, H.; Kurose, I.; Wolf, R.E.; Granger, D.N., 1994: Mechanisms of lactoferrin-induced leukocyte-endothelial cell adhesion in postcapillary venules. Objective: The objective is to determine the contributions of electrostatic charge, endothelial cell adhesion glycoproteins (P- and E-selectins), and histamine to lactoferrin-induced leukocyte adhesion in postcapillary venules. Methods: Rat mesent...

Ross, W.G., 1977: Whaling and the decline of native populations. A well-documented instance of introduced disease which cause high mortality among the Saglermiut also had an impact on other Eskimo groups. The episode shows that Eskimo groups attracted into large semi-permanent settlements by commercial 19th cen...