+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Weekly administration of paclitaxel might be beneficial against TS-1-resistant recurrent gastric cancer--a case report

, : Weekly administration of paclitaxel might be beneficial against TS-1-resistant recurrent gastric cancer--a case report. Gan to Kagaku Ryoho. Cancer & ChemoTherapy 31(8): 1237-1241

At one year after postoperative adjuvant therapy consisting of TS-1, UFT, and PSK, lymph-node metastasis and recurrent suprarenal metastasis were confirmed in a patient with Stage IV gastric cancer. Despite TS-1 therapy (120 mg/body, 4 consecutive weeks, 2-week break), the therapeutic effect remained PR, and the severity of adverse reactions, such as skin symptoms, leukopenia, and diarrhea, ranged from grade 1 to 3. Although this therapy was continued intermittently, the therapeutic effect worsened to PD and, as a result, the therapy was discontinued. Next, in accordance with the treatment of recurrent and advanced breast cancer, weekly paclitaxel (PTX 80 mg/m2, 3 consecutive weeks, 1-week break) administration was performed on an outpatient basis. CR was achieved after 4 cycles. In addition, no adverse reactions were seen. Therefore, the weekly administration of PTX for the treatment of recurrent gastric cancer resistant to 5-FU anticancer agents is extremely useful, as the antitumor effect of this therapy was great, no adverse reactions were seen, and it can be performed on an outpatient basis.


PMID: 15332551

Other references

Levkova, N.A.; Kakabadze, S.A.; Tepliakova, N.P., 1978: Synaptoarchitectonics of the ganglia of the celiac plexus in white rats. In 50 intact white rats at the age of 6, 15, 23 and 30 months synapsoarchitectonics of the celiac plexus nodes was studied by an electron microscopy method. Peculiarities in synapsoarchitectonics are stipulated by pericaryon processes in neurons,...

Lackey,J.A., 2010: Endosperm size diversity in domesticated, wild, and semiwild soybean. Past literature documents that domesticated soybean, <i>Glycine max</i> (L.) Merr., has trivial to almost nonexistent galactomannan-containing endosperm in mature dormant seeds. Current preliminary observations confirm limited endosper...

Chen, D.; Heher, K., 2005: Management of the anophthalmic socket in pediatric patients. The management of the pediatric anophthalmic socket is distinguished from adult anophthalmia, because normal socket and facial development is dependent on orbital growth. Recent literature on managing anophthalmic sockets is discussed with a focus...

Crickx, E.; Machelart, Iène.; Lazaro, E.; Kahn, J-Emmanuel.; Cohen-Aubart, F.; Martin, T.; Mania, A.; Hatron, P-Yves.; Hayem, G.; Blanchard-Delaunay, C.; de Moreuil, C.; L.G.enno, G.; Vandergheynst, Fédéric.; Maurier, Fçois.; Crestani, B.; Dhote, R.; Silva, N.Martin.; Ollivier, Y.; Mehdaoui, A.; Godeau, B.; Mariette, X.; Cadranel, J.; Cohen, P.; Puéchal, X.; L.J.unne, C.; Mouthon, L.; Guillevin, Lïc.; Terrier, B., 2016: Intravenous Immunoglobulin as an Immunomodulating Agent in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides: A French Nationwide Study of Ninety-Two Patients. Intravenous immunoglobulin (IVIG) represents a therapeutic alternative in antineutrophil cytoplasmic antibody-associated vasculitides (AAV), but its efficacy has been evaluated in only 2 small prospective trials. The aim of this study was to evalu...

Bradley, D.E.; Robertson, D., 1968: The structure and infective process of a contractile Pseudomonas aeruginosa bacteriophage. Journal of General Virology 3(2): 247-254

Marciarille, A.Marie., 2011: Healing Medicare hospital recidivism: causes and cures. American Journal of Law & Medicine 37(1): 41-80

Nakazawa, S.; Sato, H.; Watanabe, O.; Fujii, N.; Chikaoka, S., 1974: Evaluation of ampicillin-dicloxacillin combination in pediatric field (author's transl. Japanese Journal of Antibiotics 27(2): 135-140

Hagen, T.M., 2014: The circle of life: Preparing a leadership succession plan. Jems 39(1): 67-67

Eggertson, L., 2013: Baby friendly. Canadian Nurse 109(6): 36-37

Sarode, S.V.; Taley, Y.M., 1976: Joint toxicity of some organo synthetic insecticides on safflower aphid dactynotus carthami. The joint action of 8 organosynthetic insecticides, i.e., BHC, carbaryl, endosulfan, endrin, malathion, phosphamidon, phosalone and quinolphos, were studied against safflower aphid, D. carthami H.R.L., by direct spray method; observations were rec...