geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA


, : A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(II) complexes with calf thymus DNA. Metallomics 4(7): 641-644

The interactions of four antitumor azolato-bridged dinuclear platinum(II) complexes, [{cis-Pt(NH(3))(2)}(2)(μ-OH)(μ-azolato)](2+), with calf thymus DNA were monitored dose- and time-dependently, by using circular dichroism. Complexes 1-4 reacted with DNA via a two-step interaction that comprised a prompt diffusion-controlled reaction, which induced a B- to C-form transition, and a relatively slow temperature-dependent reaction.

US$19.90

PMID: 22538714

DOI: 10.1039/c2mt20022h


Other references

Golomb, B.A., 1998: Cholesterol and violence: is there a connection?. Purpose: To determine whether the seeming relation between low or lowered cholesterol levels and violence is consistent with causality according to Hill's criteria and whether construct validity is supported by convergence of findings across...

Daitch, Z.; Shields, C.L.; Say, E.A.T.; Mashayekhi, A.; Shields, J.A., 2016: Submillimeter Choroidal Melanoma Detection By Enhanced Depth Imaging Optical Coherence Tomography In A Patient With Oculodermal Melanocytosis. To describe a tiny subclinical choroidal melanoma visualized only with enhanced depth imaging optical coherence tomography in a newly symptomatic patient with known oculodermal melanocytosis. Case report. A 52-year-old white man with heterochromia...

Harris, R.M.B.; McQuillan, P.; Hughes, L., 2015: Reprint of: The effectiveness of common thermo-regulatory behaviours in a cool temperate grasshopper. Behavioural thermoregulation has the potential to alleviate the short-term impacts of climate change on some small ectotherms, without the need for changes to species distributions or genetic adaptation. We illustrate this by measuring the effect...

Zuckerman, E.; Toubi, E.; Toubi, A.; Tzykonov, I.; Sabo, E.; Keren, D.; Slobodin, G.; Yeshurun, D., 1999: Anticardiolipin antibodies in chronic hepatitis C is not associated with an increased risk for thromboembolic events. Hepatology 30(4 PART 2): 602A, Oct

Damas, C.; Vink, T.; Nieuwenhuis, H.K.rel; Sixma, J.J., 1998: The platelet alpha granule membrane protein GMP33 is identical to the N-terminus of thrombospondin. British Journal of Haematology 102(1): 146, July 1

Ford W.D.A.; Mackellar A.; Richardson C.J.L., 1980: Pre operative and post operative rectal metronidazole for the prevention of wound infection in childhood appendicitis. Children suspected of having appendicitis were treated with preoperative metronidazole per rectum and then postoperative metronidazole per rectum until the drug could be administered orally. This series shows that even when administered after anes...

Dinkla, K.; Nitsche-Schmitz, D.Patric.; Barroso, V.; Reissmann, S.; Johansson, H.M.; Frick, I-Maria.; Rohde, M.; Chhatwal, G.S., 2007: Identification of a streptococcal octapeptide motif involved in acute rheumatic fever. Acute rheumatic fever is a serious autoimmune sequela of pharyngitis caused by certain group A streptococci. One mechanism applied by streptococcal strains capable of causing acute rheumatic fever is formation of an autoantigenic complex with hum...

Anonymous, 2013: Radiation fields in star-forming galaxies the disk, thin disk and bulge. The observational signatures of many of the most fundamental physicalattributes of galaxies, including the mass of the interstellar gas in bothatomic and molecular form, the thermodynamical properties of this gas, as wellas the ambient magnetic fi...

Chang, E.I.; Carlsen, B.T.; Festekjian, J.H.; D.L.o, A.L.; Crisera, C.A., 2014: Salvage rates of compromised free flap breast reconstruction after recurrent thrombosis. Microvascular complications after free flap breast reconstruction are devastating problems that increase patient morbidity and potentially lead to flap loss. Yet, there is a dearth of literature about rates of free flap salvage after recurrent vas...

Robinet M.J.; Marchetti F.P., 1977: Implementing effective radiation protection for x ray diffraction and fluorescence analysis work. Health Physics 33(6): 659