geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity


, : A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. Journal of Clinical Dentistry 21(2): 49-55

The objective of this clinical study was to evaluate and compare the efficacy in reducing dentin hypersensitivity of an 8% strontium acetate, 1040 ppm sodium fluoride dentifrice to a marketed control 8% arginine, calcium carbonate, 1450 ppm sodium monofluorophosphate dentifrice after twice-daily brushing for two, four, and eight weeks. This was a randomized, examiner-blind, two-arm parallel group, eight-week longitudinal clinical study with seventy-nine subjects, stratified based on baseline tooth sensitivity (Schiff score, Yeaple). Subjects brushed with either an 8% strontium acetate-based dentifrice or a marketed 8% arginine calcium carbonate dentifrice twice daily for approximately one minute. At screening, baseline, weeks two, four, and eight, subjects' tooth sensitivity was determined through both evaporative (Schiff and Visual Analogue Scale [VAS]) and tactile stimuli (Yeaple probe). Subject assessments using each stimulus were performed by the same examiner throughout the study. Seventy-seven subjects completed this clinical study. Both subject groups exhibited significant cumulative reductions from baseline to Days 14, 28, and 56 in dentin hypersensitivity as measured by Schiff, Yeaple, and VAS (for the 8% strontium acetate group, p < or = 0.0001 for all time points; for the 8% arginine calcium carbonate group, p = 0.0031 for Yeaple at Day 14, p = 0.0015 for VAS at Day 14, and p < 0.0001 for all remaining measures and time points). No significant differences (p > 0.05) were observed between treatments for any of the time points and measures except for tactile sensitivity at Day 56, for which the 8% strontium acetate-based dentifrice was statistically superior (p = 0.0391) to the control 8% arginine calcium carbonate dentifrice. The 8% strontium acetate, 1040 ppm sodium fluoride dentifrice provided significant reductions in dentin hypersensitivity (p < 0.0001) after two, four, and eight weeks of product use. Comparisons to a control 8% arginine calcium carbonate dentifrice showed no significant differences (p > 0.05) apart from tactile (Yeaple) sensitivity at week 8, where the 8% strontium acetate-based dentifrice showed significant improvement over the control (p = 0.0391).

US$29.90

PMID: 20669816


Other references

Yamamoto, M., 1985: Molecular genetics of meiosis. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 30(5): 350-360

Donner, L.R., 2011: Atypical spitzoid melanocytic tumors. American Journal of Surgical Pathology 35(5): 774-774

Henderson, N.C.; Pollock, K.J.; Frew, J.; Mackinnon, A.C.; Flavell, R.A.; Davis, R.J.; Sethi, T.; Simpson, K.J., 2006: Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and is a key intracellular signalling molecule involved in con...

Bronaugh R.L.; Wester R.C.; Bucks D.; Maibach H.I.; Sarason R., 1990: In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans. The percutaneous absorption of the fragrance diethyl maleate was measured in vivo in human and monkey studies. With the application sites occluded, 54% of the applied dose of the volatile fragrance penetrated human skin in 24 hr compared with 69%...

Chang, T.F.n; Liu, Y.H.; Wang, C.N.; Miu, H.C.; Chen, S., 1963: Preliminary observation on the treatment of Paragonimiasis skrjabini with Bithionol. Forty-two cases of paragonimiasis due to Paragonimus skrjabini were treated with Bithionol with marked therapeutic effects. Bithionol alone was given every other day at the dosage of 3 g. in 3 divided doses for 20 days in 40 dases, and in combinat...

Salvin, O., 1892: Catalogue of the Picariae in the Collection of the British Museum Upupae, Trochili. Upupae, p. 43; Trochili, p. 45.

Fedorina T.A., 1980: A clinico anatomical analysis of the role of lipoid spots in the aorta in formation and development of the athero sclerotic process in children. A total of 243 aortas of children aged 1 day to 14 yr, who had died of various diseases were examined, Lipoidosis of the aorta was observed in 100% of the children over 2 yr of age. The absence of increase in the lipoidosis area in the ascending p...

Academy O.Natural Sciences O.Philadelphia (Usa)., 1999: Masked Duck Nomonyx dominica. Birds Of North America. 0(393): 1-11

Tolbert N.E., 1977: Regulation of products of photosynthesis by photo respiration and reduction of carbon. Mitsui, Akira Et Al (Ed ) Biological Solar Energy Conversion Conference, Miami, Fla , Usa, Nov 15-18, 1976 Xiii+454p Illus Maps Academic Press, Inc : New York, N Y , Usa; London, England Isbn 0-12-500650-0 243-263

Kempa, K.; Zhou, Y.; Engelbrecht, J.R.; Bakshi, P.; Ha, H.I.; Moser, J.; Naughton, M.J.; Ulrich, J.; Strasser, G.; Gornik, E.; Unterrainer, K., 2002: Intersubband transport in quantum wells in strong magnetic fields mediated by single- and two-electron scattering. We show theoretically that in quantum wells subjected to a strong magnetic field the intersubband current peaks at magnetic field values, which reveal the underlying specific intersubband scattering mechanism. We have designed and grown a superlat...