+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A comparison of rat SPECT images obtained using (99m)Tc derived from 99Mo produced by an electron accelerator with that from a reactor

, : A comparison of rat SPECT images obtained using (99m)Tc derived from 99Mo produced by an electron accelerator with that from a reactor. Physics in Medicine and Biology 58(9): 2737-2750

Recent shortages of molybdenum-99 ((99)Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce (99)Mo from which technetium-99m ((99m)Tc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced (99m)Tc with those obtained using (99m)Tc from a commercial generator were compared. Disks of (100)Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of (99)Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the (99m)Tc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using (99m)Tc from a standard reactor (99)Mo generator. The efficiency of (99)Mo-(99m)Tc separation was typically greater than 90%. This study demonstrated the delivery of (99m)Tc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced (99m)Tc were comparable. High-power electron accelerators are an attractive option for producing (99)Mo on a national scale.


PMID: 23552053

DOI: 10.1088/0031-9155/58/9/2737

Other references

Steele Moore L.; Furness K.; Holloway W.J., 1992: In vitro activities of ciprofloxacin daptomycin teicoplanin and vancomycin against clinical isolates of corynebacterium jeikeium. Abstracts of the General Meeting of the American Society for Microbiology 92: 7

Brandt, E.R.; Devenish, R.J.; Cheetham, B.F.; Linnane, A.W., 1993: Detection of human interferon-alpha-encoding gene expression. We have devised a sensitive method based on the polymerase chain reaction (PCR) to detect expression of human interferon-alpha-encoding genes (IFN-A) in general, and specifically, expression of the IFN-A2 or IFN-A4 genes. The utility of the PCR ap...

Jhaveri, A.A.; Gokhale, V.N., 1975: Ectopic pregnancy after loop insertion. Journal of Obstetrics and Gynaecology of India 25(2): 275-276

Choi Y.S.; Imasato Y.; Ikeda I.; Sugano M., 1989: Effects of dietary carbohydrates on cholesterol metabolism in rats of different ages. Male Sprague-Dawley rats aged 1 month (young) and 9 months (adult) were fed diets containing sucrose, glucose or corn starch as a carbohydrate source for 4 weeks. Dietary sucrose increased (a) the liver size in rats of both ages, (b) the serum cho...

Negrete Redondo, P.; Romero Jarero, J.; Arredondo Figueroa,, 2004: Anatibiotic resistance and presence of plasmids in Aeromonas hydrophila, Vibrio fluvialis, and Vibrio furnissii isolated from Carassius auratus auratus. We isolated and identified 70 bacterial strains from the ornate fish species Carassius auratus, in specimens with signs of infection. The isolated and identified bacterial species, Aeromonas hydrophila, Vibrio fluvialis, and Vibrio furnissii, have...

Melekian, B., 1960: Significance of a case of recurring pulmonary staphylococcal infection. La Medicina Internazionale 67: 47-50

Cromwell, Rp, 1990: Shock absorbers--what do they do and do I need new ones?. Agricultural engineering fact sheet Florida Cooperative Extension Service: (78)

Meyer, K.; Malki, M.; Reddy, J.K., 2001: Regulation of novel genes by peroxisome proliferators Identification using cDNA microarrays. Molecular Biology of the Cell 12(Supplement): 226a, Nov

Kern, T.; Kutzner, E.; Eisenreich, W.; Fuchs, T.M., 2016: Pathogen-nematode interaction: Nitrogen supply of Listeria monocytogenes during growth in Caenorhabditis elegans. Listeria monocytogenes is a Gram-positive facultatively intracellular human pathogen. Due to its saprophytic lifestyle, L. monocytogenes is assumed to infect and proliferate within soil organisms such as Caenorhabditis elegans. However, little i...

Berger, S.H.; Haddox, M.; Wargovich, M.J., 1994: Biology of aberrant colonic crypts. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 100