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A corona discharge initiated electrochemical electrospray ionization technique

, : A corona discharge initiated electrochemical electrospray ionization technique. Journal of the American Society for Mass Spectrometry 20(11): 1988-1996

We report here the development of a corona discharge (CD) initiated electrochemical (EC) electrospray ionization (ESI) technique using a standard electrospray ion source. This is a new ionization technique distinct from ESI, electrochemistry inherent to ESI, APCI, and techniques using hydroxyl radicals produced under atmospheric pressure conditions. By maximizing the observable CD at the tip of a stainless steel ESI capillary, efficient electrochemical oxidation of electrochemically active compounds is observed. For electrochemical oxidation to be observed, the ionization potential of the analyte must be lower than Fe. Ferrocene labeled compounds were chosen as the electrochemically active moiety. The electrochemical cell in the ESI source was robust, and generated ions with selectivity according to the ionization potential of the analytes and up to zeptomolar sensitivity. Our results indicate that CD initiated electrochemical ionization has the potential to become a powerful technique to increase the dynamic range, sensitivity, and selectivity of ESI experiments.


PMID: 19747843

DOI: 10.1016/j.jasms.2009.07.021

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Peck, A.L.; Harpaz, N.; Hontanosas, M.; Newkirk, C.; Greenwald, B.D.; Yin, J.; Laurin, J.; Tong, Y.; Meltzer, S.J., 1993: P53 Protein overexpression occurs early and often in neoplastic ulcerative colitis. Gastroenterology 104(4 SUPPL ): A440

Fehlhaber H W.; Girg M.; Seibert G.; Hobert K.; Welzel P.; Van Heijenoort Y.; Van Heijenoort J., 1990: Moenomycin a a structural revision and new structure activity relations. A detailed FAB MS analysis combined with NMR and chemical results requires the structure of moenomycin A to be revised from 1a to 1b. New biochemical results seem to support the assumption that in the region F-G-H of 1b the structural requirements...

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Katoh-Semba, R.; Semba, R.; Kashiwamata, S.; Kato, K., 1989: Sex-dependent and sex-independent distribution of the beta-subunit of nerve growth factor in the central nervous and peripheral tissues of mice. Levels of the beta-subunit of nerve growth factor (beta-NGF) were measured in the central nervous and peripheral tissues of mice using a highly sensitive, sandwich-type enzyme immunoassay system. Antiserum was raised in rabbits against the 7S form...

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