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A critical discussion of computer analysis in medical imaging


, : A critical discussion of computer analysis in medical imaging. Proceedings of the American Thoracic Society 4(4): 347-349

Medical imaging has increasingly provided surrogate endpoints in therapeutic trials. This use assumes that the interpretation of the images can be unbiased and reproducible and that the image attributes included in the interpretation are relevant to the mechanism of the trial. The principal motivation for computer analysis is to evaluate an attribute of the image as a metric in an algorithmic manner, independent of observer bias or variability. The metric is expected to reflect change in rough proportion with at least one aspect of the degree of disease or the effectiveness of the therapeutic intervention. If either condition is satisfied, the measure is quantitative. Visual interpretation explicitly or implicitly tends to be based on multiple image attributes. Explicit combination of multiple attributes yields composite scores. To evaluate the risk or probability of disease, they are useful. But the components of the scores can be combined only if they are mathematically isomorphic. For the evaluation of interventions, they are less useful because the effect on one component may be obscured by the lack of effect on other components. This article reviews quantification of air trapping in cystic fibrosis and quantification in general. Validation of any computer analysis can rely on agreement with visual interpreters (on average), they can be derived from first principles, or by agreement with an alternative method that measures the pathophysiological mechanism directly (xenon washout for air trapping). However, in the context of trials, the validation may come from a superior ability to detect objective change and to discriminate between affected and unaffected individuals.

US$19.90

PMID: 17652499

DOI: 10.1513/pats.200701-014HT


Other references

Litvinenko O.K.; Tygliyan A.V.; Rukin M.D., 1979: The graphic construction of a geophysical map using computers. Razvedochnaya Geofizika 87): 103-112

Fukazawa H.; Mizuno S.; Uehara Y., 1990: Effects of herbimycin a and various sulfhydryl reagents on p60v s r c kinase activity in vitro. Herbimycin A is an antibiotic which reverses transformation caused by src family oncogenes. It inactivates p60v-src in vitro, possibly by binding to reactive Sh-group(s) of the kinase. We examined effects of various SH-reagents on p60V-src and obs...

Maelicke, A., 1988: Structural similarities between ion channel proteins. Trends in Biochemical Sciences 13(6): 199-202

Seed, J.C.; Calkins, E., 1949: On the mechanism of action of 933F. Bulletin of the Johns Hopkins Hospital 84(3): 282-284

Schiestl, R.H.; Dominska, M.; Petes, T.D., 1993: Transformation of Saccharomyces cerevisiae with nonhomologous DNA: illegitimate integration of transforming DNA into yeast chromosomes and in vivo ligation of transforming DNA to mitochondrial DNA sequences. When the yeast Saccharomyces cerevisiae was transformed with DNA that shares no homology to the genome, three classes of transformants were obtained. In the most common class, the DNA was inserted as the result of a reaction that appears to requir...

Gomazkov, O.A., 1995: Basic and applied problems in current studies of regulatory peptides. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk: 10-12

Preud'homme J.L.; Klein M.; Verroust P.; Seligmann N., 1971: Membrane bound mono clonal immuno globulin in chronic lymphocytic leukemia. Revue Europeenne d'Etudes Cliniques et Biologiques 16(10): 1025-1031

Hunty, A. de la; Ashwell, M., 2007: Are people who regularly eat breakfast cereals slimmer than those who don't? A systematic review of the evidence. There is growing evidence that people who eat breakfast regularly tend to be slimmer than those who skip breakfast. However, this is not a consistent finding and it is not true for all types of breakfast. Also the relationship with breakfast can d...

Stefanescu Sabba S.; Ionescu Florian; Popovici Dorin; Stoenescu Scarlat, 1961: Prospectiuni geofizice pentru fier linga Constanta. Geophysical exploration in the vicinity of Constanta, Romania, indicated the presence of a zone of iron mineralization in amphibole schists at minimum depths of 550 meters.

Hála, K.; Vilhelmová, M.; Hartmanová, J., 1977: The structure of the major histocompatibility complex of the chicken. A review.