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A field effect transistor biosensor with a γ-pyrone derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference


, : A field effect transistor biosensor with a γ-pyrone derivative engineered lipid-sensing layer for ultrasensitive Fe3+ ion detection with low pH interference. Biosensors & Bioelectronics 54: 571-577

Field effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here a new type of transistor developed for the detection of Fe(3+) ions in which this sensing layer is made of a monolayer of lipids, engineered in such a way that it is not sensitive to pH in the acidic range, therefore making the device perfectly suitable for biomedical diagnosis. Probes are γ-pyrone derivatives that have been grafted to the lipid headgroups. Affinity constants derived for the chelator/Fe(3+) complexation as well as for other ions demonstrate very high sensitivity and specificity towards ferric ions with values as high as 5.10(10) M and a detected concentration as low as 50 fM.

US$19.90

PMID: 24333568

DOI: 10.1016/j.bios.2013.11.051


Other references

Kung, E.; Parham, G.P., 1995: Primary lymphatic dissemination of malignant elements in a mature cystic ovarian teratoma. This case of malignant transformation in a mature cystic ovarian teratoma (dermoid cyst) is significant for the atypical manner in which the malignant elements metastasized to lymph nodes without evidence of intraperitoneal dissemination. The dise...

Silliman, E.R., 1979: Relationship between pictorial interpretation and comprehension of three spatial relations in school-age children. Effects on spatial term comprehension as the result of transformations in the stimulus dimensions of six pictures containing the same three figures were explored using Piaget's concept of spatial perspective. A Modified Test of Pictorial Spac...

Agrawal, K.S.; Singla, S.; Shrotriya, R., 2016: "Text-Neck View": A New Photographic Tool for Assessment of Nasal Dorsum in Crooked Noses. Plastic and Reconstructive Surgery 138(1): 165e-167e

Svendsrud, D.H.ge; Loennechen, T.; Winberg, J.O.of, 1997: Effect of adenosine analogues on the expression of matrix metalloproteinases and their inhibitors from human dermal fibroblasts. The effect of the cytostatic and antiviral adenosine analogues 3-deazaadenosine (c-3Ado) and 3-deaza-(+-)-aristeromycin (c-3Ari) on human skin fibroblasts was studied. Variables examined were cell morphology, viability, DNA fragmentation, expressi...

D.P.rri, R.; Meduri, M.; D.R.sa, A.E.; Simone, F., 1977: Sleep spindles in healthy people: I) A quantitative, automatic analysis in young-adult subjects. Bollettino Della Societa Italiana di Biologia Sperimentale 53(12): 783-789

Austin, M.P., 1987: Models for the analysis of species' response to environmental gradients. A procedural model for vegetation analysis is presented. Suggestions are made that analysis methods can test theory as well as examine vegetation-environment correlations. Gauch and Whittaker's propositions regarding species behavioural prope...

Trivedi, C.P.; Sharma, R.D., 1974: Effect of propranolol on pituitary adrenal axis. Indian Journal of Physiology and Pharmacology 18(1): 66-67

Watts, M.A.; Innes, B.J., 1984: Calcified atrial thrombus: complication of central venous hyperalimentation. Two years and eight months after having had hyperalimentation during an infection, a 4-year-old boy was readmitted to the hospital with a viral syndrome. A chest X-ray film showed calcification over the right heart. After treatment of the viral pr...

Pittenger, Dick, 1997: WHOI and access to the sea. The strategy to be employed by the Woods Hole Oceanographic Institution (WHOI) with regard to future ocean exploration and research is outlined. The replacement of the WHOI ships Knorr and Oceanus is discussed, as is the upgrading of the submersib...

Lurie, D.J.; McCallum, S.J.; Hutchison, J.M.; Alecci, M., 1996: Continuous-wave NMR imaging of solids. Current pulsed nuclear magnetic resonance methods of imaging samples such as solids with short spin-spin relaxation times are restricted to use with T2 values longer than approximately 10 microseconds. In the present study a method of imaging ultr...