geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females


, : A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. Journal of Thoracic Oncology 9(11): 1647-1655

It has been estimated that the proportion of never-smokers among females with lung cancer is 53% worldwide and 75% in Korea. We conducted a two-stage study to identify genetic factors responsible for lung cancer susceptibility in female never-smokers. In a discovery set, 1969 potentially functional single nucleotide polymorphisms (SNPs) of 1151 genes, which were related to cancer development and progression, were evaluated using the Affymetrix custom-made GeneChip in 181 female never-smokers with lung cancer and 179 controls. A replication study was performed on an independent cohort of 596 cases and 1194 healthy controls. Sixteen SNPs with p < 0.05 for genotype distribution in the discovery set were enrolled in the replication study. Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] rs13009079T>C) were found to be significantly associated with lung cancer in the same direction as the discovery set. Homology-based model for CSF1R indicated that the rs10079250A>G leads to increased positive charge of CSF-binding region of CSF1R, thereby increasing the chance of binding between CSF and CSF1R. In addition, this SNP was found to increase the phosphorylation of a mitogen-activated protein kinase, JNK. Our results suggest that the three SNPs, particularly CSF1R rs10079250, may contribute to lung cancer susceptibility in never-smoking females.

US$19.90

PMID: 25144241

DOI: 10.1097/JTO.0000000000000310


Other references

Bartsch I., 1988: Halacaridae acari from the northern atlantic ocean description of halacarus balgimus new species and agauides cryosi new genus new species. Sediment samples collected in the Ibero-Moroccan bay (Gulf of Cadiz) held two halacarid species, Halacarus balgimus, a shallow-water species, and AGAUIDES cryosi gen. et sp. n., a deep-sea form. The two species are described.

Volin, L., 1967: Khruschev and the Soviet agricultural scene. An attempt is made to assess the role of Khrushchev in agricultural policy-making in the USSR, the main aim of which he saw as the need to increase production as rapidly and economically as possible. The main reforms he introduced were: (1) increa...

Benvenuti, S.; Severi, F.; Costantino, L.; Vampa, G.; Melegari, M., 1998: Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives. A series of N-(4-methoxy, 4-fluoro, 4-trifluoromethyl and 4-nitrobenzoyl)-L-amino acids was synthesized and their inhibitory activity towards bovine lens aldose reductase (ALR2) was tested.

Kudriavtseva, G.; Siusiukin, A.; Rodichkin, V.; Prokhorov, V., 1979: Influence of the pH of the medium on the morphology of BP cell cultures and their susceptibility to foot-and-mouth disease virus. Veterinariia (2) 33-34

Anonymous, 2012: Perforation of the right ventricle during cardiac resynchronisation therapy upgrade not related to a coexisting persistent left superior vena cava. Right ventricle (RV) perforation is a complication that may arise during device implants. We present the case of a patient undergoing cardiac resynchronisation therapy upgrade that was complicated with an RV perforation. The lead was successfully...

Campbell, L.M.; Szabo, R.A.; Barton, D.; Greenwood, D.; Hecky, R.E., 2003: The role of round goby and other fish species in food web dynamics of Lake Erie. IAGLR Conference Program & Abstracts 46: 244

Nabkahira, K., 1987: Sexual behavior of the nursery-web spiders, Dolomedes sulfureus and D. pallitarsis. Atypus, 20-22 No. 89

Small, J.D.; Albertsen, P.C.; Graydon, R.J.; Ricci, A.; Sardella, W.V., 1992: Adenoid cystic carcinoma of Cowper's gland. We report an additional case of primary adenoid cystic carcinoma of Cowper's gland in an otherwise healthy asymptomatic 66-year-old man. Based on a review of similar lesions presenting in the head and neck, our treatment plan entailed pelvic...

Self, J.B., 1968: A gastric reconstruction. British Journal of Surgery 55(8): 602-604

de Athayde Filho, P.F.; Howe, B.P.; Miller, J., 2008: Correction: Considerations in Platinum and Gold Drug Design and the Synthesis of Chloro-(2,3-Diphenyl-1,3,4-Thiadiazolium M-5-Thiolato-S(exo))Gold(1): The First Gold-Mesoionic Complex of its Kind. Metal-Based Drugs 6(3): 194-194