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A new kaempferol trioside from Silphium perfoliatum

, : A new kaempferol trioside from Silphium perfoliatum. Journal of Asian Natural Products Research 16(4): 393-399

A new apiose-containing kaempferol trioside, kaempferol-3-O-α-L-rhamnosyl-(1‴ → 6″)-O-β-D-galactopyranosyl-7-O-β-D-apiofuranoside, along with 16 known compounds, were isolated from 50% acetone extract of Silphium perfoliatum L. Their structures were elucidated by acid hydrolysis and spectroscopic techniques including UV, IR, MS, ¹H, ¹³C, and 2D-NMR. In addition, the pharmacological activity of compound 1 was tested with HepG2 and Balb/c mice (splenic lymphocytes and thymic lymphocytes) in vitro, and it exhibited inhibitory effect on the proliferation of HepG2 cells and showed the immunosuppressive activity.


PMID: 23919684

DOI: 10.1080/10286020.2013.823951

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