+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A new neural imaging approach using a CMOS imaging device

, : A new neural imaging approach using a CMOS imaging device. Conference Proceedings 1: 1061-1064

We have developed and demonstrated the use of a dedicated CMOS device for in vivo functional imaging of the mouse brain. In order to achieve this, a 176 x 144 pixel array image sensor is designed, fabricated and specially packaged using a novel process. By using on-chip fluorescence imaging configuration, we have successfully imaged deep inside the hippocampus of the mouse brain. Functional imaging is verified by using a fluorogenic substrate that detects the presence of serine protease in the brain. Introduction of kainic acid induces the expression of the serine protease. The protease reacts with the substrate which then fluorescence. By imaging and measuring the fluorescence signal, we have successfully measured the brain protease activity and accurately determined its reaction onset. This method represents a novel approach for neural imaging.


PMID: 17945618

DOI: 10.1109/IEMBS.2006.260316

Other references

Hirakawa, S.; Koizumi, T-aki., 2014: Synthesis and dynamic behavior of an anthyridine-ligated ruthenium complex. A ruthenium complex containing a 1,9,10-anthyridine derivative, [Ru(L)(bpy)2](PF6)2 ([1](PF6)2; L = 1,13,14-triazadibenz[a,j]anthracene, bpy = 2,2'-bipyridyl), was synthesized. X-ray crystal structural analysis of [1](PF6)2 showed that L is c...

Szluinska, M.; Edwards, A.A.; Lloyd, D.C.; B.O.e, G.V.jayalaxmi, X, 2007: Statistical methods for biological dosimetry. Statistical methods most commonly employed in biological dosimetry by analysis of chromosomal aberrations in blood lymphocytes are reviewed illustrate the principles underlying the approaches to assessing data from differing types of radiation ove...

Schulz, S., 1983: Various aspects of managing experimental animals and of animal protection legislation in cases of diseased dogs in Marburg area 1974-1982. (1). Dtw. Deutsche Tierarztliche Wochenschrift 90(3): 95-101

Banting, A.D.-L.L.venant, M.L.-Bars, H., 1980: Study of a method of early weaning and the economics of milk replacement feeding of heifers. Revue de medecine veterinaire 131(2): 137-140

Ram, B., 1981: We must create jobs, more jobs. The paper describes the efforts being made by the Government of India to create more employment through its various schemes, such as the National Rural Employment Programme, Food for Work Programme, Integrated Rural Development Programme, Training...

Cunningham Charles G.; Barton Paul B.J., 1984: Recognition and use of paleothermal anomalies as a new exploration tool. Abstracts with Programs - Geological Society of America 16(6): 481

Price, A.B., 1959: Medical reports for disability claims. American Journal of Nursing 59(4): 538-539

Anonymous, 1954: HAROLD HILL Health Centre. Lancet 267(6843): 866-867

Kido, A.; Stein, R.B., 2002: Effect of aging on h reflex and spinal inhibition. The purpose of this study was to study an excitatory H-reflex and reciprocal inhibition in healthy subjects from a variety of age groups. Since the population with CNS disorders is distributed over a wide range of ages, responses in age matched gr...

Borowsky, Alexander D., 2003: Comparative pathology of mouse models of human cancers Genetically engineering a mouse. Comparative Medicine (Memphis) 53(3): 249-250, June