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A pilot study of the effect of intravenous erythropoetin on improvement of visual function in patients with recent indirect traumatic optic neuropathy

, : A pilot study of the effect of intravenous erythropoetin on improvement of visual function in patients with recent indirect traumatic optic neuropathy. Graefe's Archive for Clinical and Experimental Ophthalmology 252(8): 1309-1313

To evaluate the efficacy of intravenous erythropoietin (EPO) on improvement of visual function and color vision in patients with recent indirect traumatic optic neuropathy (TON). In a case series, 18 eyes of 18 patients with diagnosis of indirect TON with duration of less than 2 weeks underwent 20,000 IU intravenous EPO injections daily for 3 days. Best corrected visual acuity (BCVA) and color vision were checked by Ishihara test before, 1, and 3 months after injections. BCVA and color vision were compared before, 1, and 3 months after injections. The mean BCVA improved from a baseline of 2.21 ± 0.97 to 1.48 ± 1.29 and 1.31 ± 1.27 log MAR at months 1 and 3, respectively. The differences were statistically significant (P = 0.001, P < 0.001). Color vision was changed from a baseline 2.24 ± 4.29 to 2.94 ± 4.64 and 3.41 ± 5.09 plates at months 1 and 3, respectively. We observed some qualitative improvement that was, however, statistically insignificant at the time of evaluation. (P = 0.063, P = 0.068). This case series showed noticeable effect of EPO on improvement of visual function in patients with recent indirect TON.


PMID: 24986593

DOI: 10.1007/s00417-014-2691-6

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Orliaguet, T.; Darcha, C.; Déchelotte, P.; Vanneuville, G., 1994: Meckel's cartilage in the human embryo and fetus. This work studied the development of the ventral part of Meckel's cartilage in a series of human embryos (classified in stages) and fetuses. These stages appeared particularly important: stage 16, appearance of Meckel's cartilage; stage...

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Healy, J.W.; Levine, L., 1962: Immuno-chemical demonstration of a brain deoxyribonuclease active on denatured deoxyribonucleic acid. Neurology 12(4): 304

Meyer B.S.; Krishnan T.; Clayton D.D., 1995: NSE is not necessarily a good guide to the synthesis of calcium-48. Meteoritics and Planetary Science 30(5): 548

W.K.Y.; M.D.nald C.E.; Frohberg R.C., 1971: Effect of nitrogen fertilization on protein gluten nonprotein nitrogen ammonia and nitrate content of wheat m. Cereal Science Today 16(9): 311

Aggarwal, A.; Tandon, S.; Kumar Singla, S.; Tandon, C., 2012: A Novel Antilithiatic Protein from Tribulus terrestris Having Cytoprotective Potency. Adhesion of calcium oxalate (CaOx) crystals to kidney cells is a key event in kidney stones associated with marked hyperoxaluria. As the propensity of stone recurrence and persistent side effects are not altered by surgical techniques available, p...

Simon Steven B.; Haggerty Stephen E., 1979: Petrography and olivine mineral chemistry of chondrules and inclusions in the Allende meteorite. Proceedings of the Lunar and Planetary Science Conference 10, Vol

Tseitlina, Mme B.B., 1964: An experiment in the control of fungus diseases in the Al'keev district of Tatar. A series of preventive measures in 1961-mass examination, organized meetings and talks on epidemiology, diagnosis and treatment of dermatomycoses, daily inspection of suspicious cases for 2 months, and isolation and treatment of infected persons-...

Jaramillo Robledo, A.; Santos, J.M. dos, 1980: Balance of solar radiation in coffee cultivars Catuai and Yellow Bourbon. The canopies of coffee cvs Catuai and Yellow Bourbon intercepted 96 and 95%, respectively, of the solar radiation. In Catuai the outer canopy layer intercepted 88% of the light, the inner layers 8%, and 4% reached the soil surface. In Yellow Bourb...