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A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents

, : A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. Bioorganic & Medicinal Chemistry Letters 20(22): 6712-6715

A simple and rapid NMR method is described to determine the logP of pharmaceutical agents. This method is highly versatile and efficient, because it does not require the use of deuterated solvents or the addition of any internal/external standards to the sample. We demonstrate that logP can be accurately measured using NMR for pharmaceutical agents with known logP values. Our proposed method is made possible by the combination of state-of-the-art NMR techniques including the solvent concentration reference and robust solvent suppressions.


PMID: 20864340

DOI: 10.1016/j.bmcl.2010.08.145

Other references

Stromqvist B., 1985: Scintimetric evaluation of bone metabolism. Acta Orthopaedica Scandinavica 56(2): 174-175

Gupta, V.K.; Prasad, K.S.; Bakshi, M.P.S.; Langar, P.N., 1986: Improving the nutritive value of groundnut shells through fungal cultivation. Out of 11 different fungi inoculated into short-time acid-pretreated groundnut shells (GNS), only 3 fungal species, Coprinus, Sclerotium and Sporotrichum pulvurentum, resulted in true protein content increase, up to 10%, in the substrate. Trials w...

Gminski J.; Weglarz L.; Drozdz M.; Goss M., 1991: Pharmacological modulation of the antioxidant enzymes activities and the concentration of peroxidation products in fibroblasts stimulated with elastin peptides. 1. Elastin peptides (kappa-elastin) prepared by alcoholic potassium hydroxide degradation of insoluble elastin were shown to increase the activities of antioxidant enzymes (SOD, CAT, GSH-Px) and the lipid peroxide concentration within fibroblasts....

Jackson S.; Black S.H., 1971: Ultrastructure of treponema pallidum following lysis by physical and chemical methods part 1 envelope wall membrane and fibrils. Archiv fuer Mikrobiologie 76(4): 308-324

Ramberg H., 1978: Experimental and theoretical studies related to thrust nappes. Abstracts with Programs - Geological Society of America 10(7): 475

Albizua, E.; Gallardo, M.; Barrio, S.; Rapado, I.; Jimenez, A.; Ayala, R.; Rueda, D.; Sanchez-Espiridion, B.; Puigdecanet, E.; Espinet, B.; Florensa, L.; Besses, C.; Martinez-Lopez, J., 2011: Differential expression of JAK2 and Src kinase genes in response to hydroxyurea treatment in polycythemia vera and essential thrombocythemia. This study investigates the differential gene expression profile of JAK2(V617F)-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemi...

Vogel J.C.; Waterbolk H.T., 1964: Groningen radiocarbon dates V. Carbon-14 dates are reported for old-world and new-world archaeologic samples from the Netherlands and Lesser Antilles, and for the Piltdown skull.

Sziklas, V.; Petrides, M.; Leri, F., 1993: Performance on a conditional associative learning task following lesions to the mammillary region. Society for Neuroscience Abstracts 19(1-3): 364

Colombo, Nália.Helena.; Pereira, J.Augusto.; da Silva, Márjully.Eduardo.Rodrigues.; Ribas, Lís.Fernanda.Fonseca.; Parisotto, Tís.Manzano.; Mattos-Graner,; Smith, D.J.; Duque, C., 2016: Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood. Archives of Oral Biology 67: 22-27

Hamilton, K.R.; Sinha, R.; Potenza, M.N., 2015: Self-reported impulsivity, but not behavioral approach or inhibition, mediates the relationship between stress and self-control. Stress has been associated with poor self-control. Individual differences in impulsivity and other behavioral tendencies may influence the relationship of stress with self-control, although this possibility has not been examined to date. The prese...