geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A randomized, parallel-group, open-label trial of recombinant human erythropoietin vs preoperative autologous donation in primary total joint arthroplasty: effect on postoperative vigor and handgrip strength


, : A randomized, parallel-group, open-label trial of recombinant human erythropoietin vs preoperative autologous donation in primary total joint arthroplasty: effect on postoperative vigor and handgrip strength. Journal of Arthroplasty 22(3): 325-333

This randomized trial assessed the effect of recombinant human erythropoietin (EPO) vs preoperative autologous donation (PAD) on postoperative vigor and handgrip strength in patients undergoing primary total joint arthroplasty. Adults with baseline hemoglobin level of 11 to 14 g/dL received EPO (600 IU/kg once weekly for 4 doses, n = 130) or PAD (n = 121) before primary, unilateral hip or knee arthroplasty. Mean changes in vigor score and handgrip strength from baseline were not significantly different between treatment groups. Multivariate analyses found a significant treatment effect favoring EPO over PAD for vigor, but not for handgrip strength. Patients in the EPO group had higher hemoglobin levels and required fewer transfusions. Both treatments were well tolerated. Additional study is needed to elucidate the influence of blood management strategies on postoperative vigor.

US$19.90

PMID: 17400086

DOI: 10.1016/j.arth.2006.11.002


Other references

Cagini, P.; Caticchio, R.; Santilli, E.; Fifi, A.R.; Trabalza, N., 1978: Neonatal hyperbilirubinemia and drug therapy of labor. Minerva Pediatrica 30(14): 1137-1142

Page, R.J.; Laidlaw, H.J., 1981: The construction of a traditional Egyptian beehive. American bee journal 121(3): 178-180

Baba, D.; Maita, N.; Jee, J-Goo.; Uchimura, Y.; Saitoh, H.; Sugasawa, K.; Hanaoka, F.; Tochio, H.; Hiroaki, H.; Shirakawa, M., 2006: Crystal structure of SUMO-3-modified thymine-DNA glycosylase. Modification of cellular proteins by the small ubiquitin-like modifier SUMO is important in regulating various cellular events. Many different nuclear proteins are targeted by SUMO, and the functional consequences of this modification are diverse....

Pilatus, U.; Aboagye, E.; Artemov, D.; Mori, N.; Ackerstaff, E.; Bhujwalla, Z.M., 2001: Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy. Changes in molecular expression or apoptotic behavior, induced by malignant transformation or anticancer treatment, are frequently reflected in cellular metabolism and oxygen consumption. A technique to monitor oxygen consumption, cell physiology,...

Dorokhov, Y.L.; Skurat, E.V.; Frolova, O.Yu.; Gasanova, T.V.; Smirnov, A.A.; Zvereva, S.D.; Ivanov, P.A.; Ravin, N.V.; Zamchuk, L.I.; Atabekov, I.G., 2004: Reciprocal dependence between pectinmethylesterase gene expression and tobamovirus reproduction effectiveness in Nicotiana benthamiana. Doklady. Biochemistry and Biophysics 394: 30-32

Simon, M.; Pavlik, P.; Hartig, A.; Binder, M.; Hamilton, B., 1994: The C-terminal domain of the Sc ADR1 transcription factor is necessary for regulation of peroxisome proliferation by fatty acids. Acta Histochemica et Cytochemica 27(4): 378

Anonymous, 1953: Department of Agriculture. Technical and Specialist Officers' Reports for the year 1951. INVESTIGATIONS REPORTED: 1. Soil Conservation Service, Annual Report 1951. By D. Thornton, pp. 1-11. Grasses tested were Pennisetum salifex, useful for protecting steep slopes and large waterways; Digitaria swazilandensis, for bench-terrace faces...

Giuffrida, A.; Pulvirenti, S., 1995: Bovine case of renal mycosis: histopathology and pathogenesis. Pale necrotic areas were found in the kidneys of an otherwise apparently normal bullock at meat inspection. A renal lymph node was enlarged and haemorrhagic. Histological findings indicated an Aspergillus infection.

Vlahovicek, K.; Munteanu, M.G.; Pongor, S., 1999: Sequence-dependent modelling of local DNA bending phenomena: Curvature prediction and vibrational analysis. Bending is a local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified. Bending can be predicted by simple static geometry models as well as by a recently developed elastic m...

Mancio-Silva, L.; Scherf, A., 2013: In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum. Fluorescence-based techniques have been used extensively in the malaria field to study the functional role of nuclear organization and gene positioning in blood stages of the human malaria parasite, Plasmodium falciparum. In this chapter, we prese...