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A reliable and safe method of collecting blood samples from implantable central venous catheters for determination of plasma gentamicin concentrations


, : A reliable and safe method of collecting blood samples from implantable central venous catheters for determination of plasma gentamicin concentrations. PharmacoTherapy 31(8): 776-784

To evaluate the extent of agreement between plasma gentamicin concentrations determined from samples collected by using implantable subcutaneous central venous catheters (ports) with the push-pull method and those collected by finger lancet punctures in children with febrile neutropenia. Prospective, randomized study. University-affiliated, tertiary care hospital. Sixty-two children with cancer who had single- or double-lumen ports and who received gentamicin for treatment of febrile neutropenia between February 2008 and October 2009. One blood sample was collected from the port by using the push-pull method at the same time one blood sample was collected by finger lancet puncture for determination of plasma gentamicin concentrations. Forty-four pairs of samples were available for assessment of agreement, and 43 were available for pharmacokinetic analysis. Agreement between plasma gentamicin concentrations determined from blood samples from ports and finger lancet punctures was assessed by the intraclass correlation coefficient (ICC), Bland-Altman analysis, and comparison of simulated dosage adjustments. Changes in port patency were monitored for 1 week after port sampling. Differences in simulated dosage adjustments calculated by using either the port or finger lancet puncture samples that differed by greater than 20% were considered clinically significant. Agreement between the 44 finger lancet puncture and port sample pairs was excellent (ICC 0.991, 95% confidence interval 0.984-0.995). Port plasma gentamicin concentrations were 4.7% lower than those concentrations determined in blood from finger lancet punctures. The observed limits of agreement ranged from -20.5% to 11%. Differences in dosage adjustments calculated by using port and finger lancet puncture plasma gentamicin concentrations were not clinically significant in 38 (88%) of 43 cases. No changes in port patency were observed in the week after port sampling. The push-pull method of blood sampling is a reliable and safe option for determining plasma gentamicin concentrations in children with ports.

US$19.90

PMID: 21923604

DOI: 10.1592/phco.31.8.776


Other references

Prenant, A., 1897: Notes cytologiques. IV. Deux faits d'action morphogene reciproque ou d'induction vitale entre elements cellulaires. Archiv fuer Mikroskopische Anatomie, I 427-434

McCaffery, M., 2000: Helping patients who deny pain. Nursing 29(10): 14-14

Gorelick, N.J., 1995: Overview of mutation assays in transgenic mice for routine testing. There is scientific and regulatory interest in using mutation assays in transgenic mice in safety assessments for new chemicals and drugs. Currently these assays are in the process of being validated, and protocols for routine testing are being de...

Bilecen, Süleyman.; de Groot, J.A.H.; Kalkman, C.J.; Spanjersberg, A.J.; Brandon Bravo Bruinsma, G.J.; Moons, K.G.M.; Nierich, A.P., 2017: Effect of Fibrinogen Concentrate on Intraoperative Blood Loss Among Patients With Intraoperative Bleeding During High-Risk Cardiac Surgery: A Randomized Clinical Trial. Label="Importance">Fibrinogen concentrate might partly restore coagulation defects and reduce intraoperative bleeding.Label="Objective">To determine whether fibrinogen concentrate infusion dosed to achieve a plasma fibrin...

Khaliq M.A.; Husain R.; Seth P.K.; Srivastava S.P., 1991: Effect of dibutyltin dilaurate on regional brain polyamines in rats. Administration of dibutyltin dilaurate (DBTL: 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels...

Roberts R.M., 1988: Management of human parvovirus infection in pregnancy. American Journal of Human Genetics 43(3 SUPPL): A246

Nowacka H., 1991: Stability of resistance to benzimidazole fungicides in venturia inaequalis cke aderh. Poor effect of scab control was found in 1990 on Rumilite (15% triflumizole + 45% thiophanate-methyl) treated McIntosh apple trees and virtually no effects on Topsin M (70% thiophanate-methyl) treated ones. Benzimidazole resistance was stated in t...

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Beky, A., 1986: Tending of oak stands for seed production. Tending fellings are preceded by permanent marking of the selected seed trees which should have the best stem form in the stand. The poorly formed trees, with presumably unfavourable genotypes, are felled first among the emergents and dominants. T...

Amar, H.S.S.; Ho, J.J.; Mohan, A.J., 1999: Human immunodeficiency virus prevalence in women at delivery using unlinked anonymous testing of newborns in the Malaysian setting. Objective: To determine the community prevalence of human immunodeficiency virus (HIV) in women at the time of delivery in a Malaysian setting. Methodology: Cord blood samples from a pilot screening programme for congenital hypothyroidism in 1995...