geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A retrospective comparison between preoperative and postoperative Breslow depth in primary cutaneous melanoma: how preoperative shave biopsies affect surgical management


, : A retrospective comparison between preoperative and postoperative Breslow depth in primary cutaneous melanoma: how preoperative shave biopsies affect surgical management. Journal of Drugs in Dermatology 13(5): 531-536

Accurate histopathologic staging of preoperative biopsy specimens is critical for determining optimal surgical management for patients with primary cutaneous melanoma. The American Academy of Dermatology (AAD) and National Comprehensive Cancer Network (NCCN) currently list narrow excisional biopsy (fusiform excision) as the preferred technique for biopsying lesions suspicious for melanoma. However, preoperative shave biopsies are routinely performed on lesions concerning for melanoma in many medical centers out of convenience. The current retrospective chart review was performed to determine whether preoperative shave biopsies are acceptable for evaluating lesions suspicious for melanoma and whether shave biopsies lead to underestimation of Breslow depth great enough to require additional surgeries. A consecutive sample of 242 primary cutaneous melanoma cases surgically excised between January 1, 2004 and December 31, 2010 in a private practice setting was analyzed for this study. Breslow depth underestimation occurred in 8 of 226 shave biopsy cases (3.5%). Differences in preoperative and postoperative Breslow depths in shave biopsy cases were not statistically significant (P=0.48). Underestimation of Breslow depth, melanoma transection, positive deep biopsy margins, and tumor upstaging did not lead to statistically significant changes in surgical management. Based on the results from the current study and available literature, the authors posit that preoperative deep excisional shave biopsies performed by dermatologists are accurate for determining Breslow depth and for planning surgical management of melanomas.

US$29.90

PMID: 24809875


Other references

Garcha G.; Imrie P.R.; Marley E.; Thomas D.V., 1983: Effects of mono amine oxidase inhibitor pre treatment on the fate of intra duodenally instilled carbon 14 labeled beta phenethylamine. British Journal of Pharmacology 80(SUPPL): 624P

Piepgras, D.G., 2001: Occlusive hyperemia. Journal of Neurosurgery 95(1): 165-167

Weber I.; Stephan T.; Jessberger E.K., 2004: Evaluation of preparation and measuring techniques for interplanetary dust particles for the MIDAS experiment on Rosetta. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 35: (unpaginated

Millili, P.G.; Yin, D.H.; Fan, H.; Naik, U.P.; Sullivan, M.O., 2016: Formulation of a peptide nucleic acid based nucleic acid delivery construct. Gene delivery biomaterials need to be designed to efficiently achieve nuclear delivery of plasmid DNA. Polycations have been used to package DNA and other nucleic acids within submicrometer-sized particles, offering protection from shear-induced o...

Panosyan G.A.; Vardapetyan R.R.; Vardevanyan P.O., 1978: Dna complex melting with homologous and heterologous histones. Biologicheskii Zhurnal Armenii 31(7): 689-696

Chung, L.W.K.; Gao, C.; Li, W.; Zhau, H.E., 1993: Stromal-epithelial interaction Implications for prostate tumorigenesis. Cancer Bulletin (Houston) 45(5): 430-435

Stangel, W.; Izakovic, J., 1966: Contribution on the familial occurrence of P antibodies. Folia Haematologica 86(4): 459-463

Hume George Sherwood, 1927: Oil and gas developments in Canada. Journal of the Institution of Petroleum Technologists 13(63): 607-609

Loch, J.P.; Hoekstra, R., 1987: Traces of plant pesticides in ground water--concepts and initial results of studies of soils of higher permeability in the Netherlands. Schriftenreihe des Vereins für Wasser-, Boden- und Lufthygiene 68: 247-264

Chiorescu; Wernsdorfer; Muller; Bogge; Barbara, 2000: Butterfly hysteresis loop and dissipative spin reversal in the S = 1/2, V15 molecular complex. Time resolved magnetization measurements have been performed on a spin 1/2 molecular complex, so-called V15. Despite the absence of a barrier, magnetic hysteresis is observed over a time scale of several seconds. A detailed analysis in terms of a...