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A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1--letter

, : A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1--letter. Cancer Research 74(17): 4946-4947


PMID: 25136073

DOI: 10.1158/0008-5472.CAN-13-2457

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Costa-Pinto, F.Azevedo.; Basso, A.Salgado.; Britto, L.Roberto.Giorgetti.; Malucelli, B.Eurico.; Russo, M., 2004: Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma. Allergic asthma is characterized by intermittent airway obstruction, inflammation, airway hyperreactivity, and increased production of IgE. The pathophysiology of asthma is well understood but little is known about its influences on brain activity...

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Tabata, S.; Yamamoto, M.; Goto, H.; Hirayama, A.; Ohishi, M.; Kuramoto, T.; Mitsuhashi, A.; Ikeda, R.; Haraguchi, M.; Kawahara, K.; Shinsato, Y.; Minami, K.; Saijo, A.; Hanibuchi, M.; Nishioka, Y.; Sone, S.; Esumi, H.; Tomita, M.; Soga, T.; Furukawa, T.; Akiyama, S-Ichi., 2017: Thymidine Catabolism as a Metabolic Strategy for Cancer Survival. Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism co...

Hamadain, E.I.; Chambers, H.W., 2001: Susceptibility and mechanisms underlying the relative tolerance to five organophosphorus insecticides in tobacco budworms and corn earworms. Laboratory investigations were conducted to explain the higher insecticide tolerance in tobacco budworm (TBW) relative to corn earworm (CEW). The acute toxicities of five organophosphorus (OP) insecticides to TBW and CEW laboratory colonies were f...

Dérand, T., 1995: Porcelain bond to laser-welded titanium surfaces. The purpose of this investigation was to determine if laser-welding titanium had an effect on the bond strength of porcelain to metal. This is an important consideration since the metal copings for many multi-unit porcelain restorations are fabric...

Hoving, S.; Heeneman, S.; Gijbels, M.J.J.; te Poele, J.A.M.; Russell, N.S.; Daemen, M.J.A.P.; Stewart, F.A., 2008: Single-dose and fractionated irradiation promote initiation and progression of atherosclerosis and induce an inflammatory plaque phenotype in ApoE(-/-) mice. Purpose: Increased risk of atherosclerosis and stroke has been demonstrated in patients receiving radiotherapy for Hodgkin's lymphoma and head-and-neck cancer. We previously showed that 14 Gy to the carotid arteries of hypercholesterolemic A...

Sidhu, G.S.; Khush, G.S., 1984: Allelic relationships of dominant genes for resistance to green leafhopper in four varieties of rice. The varieties DS1, Khama 49/8, ARC6602 and ARC7007, each with monogenic resistance, were crossed with ASD8, which is homozygous for the resistance gene Glh5, and the F1 and F3 were artificially infested with Nephotettix virescens. The results indi...

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Guzman, J.; Esmail, R.; Irvin, E.; Bombardier, C., 1997: A systematic review of multidisciplinary team approaches for the treatment of chronic low back pain. Arthritis & Rheumatism 40(9 SUPPL ): S310, Sept