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A theoretical method to improve and optimize the design of bioartificial livers

, : A theoretical method to improve and optimize the design of bioartificial livers. Biotechnology and Bioengineering 106(6): 980-988

Bioartificial livers (BALs) are a potentially effective countermeasure against liver failure, particularly in cases of acute or fulminant liver failure. It is hoped these devices can sustain a patient's liver function until recovery or transplant. However, no large-scale clinical trial has yet proven that BALs are particularly effective and evidently design issues remain to be addressed. One aspect of BAL design that must be considered is the mass transfer of adequate oxygen to the hepatocytes within the device. We present here a mathematical modeling approach to oxygen mass transport in a BAL. A mathematical model based upon Krogh cylinders is outlined to describe a diffusion-limited hollow fiber bioreactor. In addition, operating constraints are defined on the system--cells should not experience hypoxia and the cell population should be of adequate size. By combining modeling results with these operating constraints and presenting the results graphically, "operating region" charts can be constructed for the hollow fiber BAL (HF-BAL). The effects of varying various operating parameters on the BAL are then established. It is found that smaller radii and short, thin walled fibers are generally advantageous while cell populations in excess of 10 billion could be supported in the BAL with a plasma flow rate of 200 mL/min. For fibers of intermediate length and lumen radius, the minimum number of fibers required to produce a viable design ranges approximately from 7,000-10,000. In theory, this may be enough to support patients with failing livers.


PMID: 20506230

DOI: 10.1002/bit.22765

Other references

Wagner, H.M.; Barlage, S.; Torzewski, M.; Reichle, A.; Holler, E.; Schmitz, G.; Andreesen, R.; Rothe, G., 2000: Expression of costimulatory molecules and MHC class II antigens on blast cells in acute myeloid leukemia. Recognition of leukemic cells by T-cells and consecutive activation of T-cells may play an important role in immune surveillance of minimal residual disease after chemotherapy or allogeneic stem cell transplantation for the treatment of leukemia....

Kozlowska, M.; Goclon, J.; Rodziewicz, P., 2016: Intramolecular Hydrogen Bonds in Low-Molecular-Weight Polyethylene Glycol. We used static DFT calculations to analyze, in detail, the intramolecular hydrogen bonds formed in low-molecular-weight polyethylene glycol (PEG) with two to five repeat subunits. Both red-shifted O-H⋅⋅⋅O and blue-shifting C-H⋅⋅⋅O hydr...

Pu, F.; Ran, X.; Ren, J.; Qu, X., 2016: Artificial tongue based on metal-biomolecule coordination polymer nanoparticles. We construct an array-based recognition system (the so-called artificial tongue) through the self-assembly of nucleotides, dyes and lanthanide ions. Metal ions are selected as model analytes for verifying its discrimination ability. The work provi...

Smith, A.M.; Lattimer, J.K.; Rezvan, M., 1973: Current therapy for undescended testicle. Rationale for treatment between ages four and five. New York State Journal of Medicine 73(21): 2552-2560

Karssen, C.M., 1982: Seasonal patterns of dormancy in weed seeds. Present knowledge of field behaviour of weed seeds and the main principles of environmental control of seed behaviour in the field are described with particular attention given to studies on seasonal periodicity and dormancy. In general, seed char...

Andreev, A.A., 1977: Method for measuring oxygen tension in the muscle tissue of freely swimming hydrobionts. A miniature O2 gauge was developed for registration of PO2 [oxygen partial pressure] in the muscle of freely swimming hydrobionts. Tests were conducted on Rutilus rutilus lacustris, Leuciscus leuciscus baicalensis and Acanthogammarus victorii usin...

Iannucci, G.; Mascalchi, M.; Salvi, F.; Filippi, M., 2000: Vanishing Balo-like lesions in multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry 69(3): 399-400

Morsdorf D.; Karcher K.H., 1968: Supervision of the patient in the inst hyper baric oxygenation tank. Strahlentherapie 135(4): 407-408

Anonymous, 1981: Control of blood sugar in insulin-dependent diabetes. New England Journal of Medicine 304(15): 908-909

Hirano, S.; Tominaga, Y.; Ichinoe, A.; Ushijima, Y.; Tsuchimoto, D.; Honda-Ohnishi, Y.; Ohtsubo, T.; Sakumi, K.; Nakabeppu, Y., 2003: Mutator phenotype of MUTYH-null mouse embryonic stem cells. To evaluate the antimutagenic role of a mammalian mutY homolog, namely the Mutyh gene, which encodes adenine DNA glycosylase excising adenine misincorporated opposite 8-oxoguanine in the template DNA, we generated MUTYH-null mouse embryonic stem (...