geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project


, : ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. Blood 111(12): 5496-5504

The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and treated at their respective centers. Of the 1314 eligible patients, 181 had anaplastic large-cell lymphoma (ALCL; 13.8%) on consensus review: One hundred fifty-nine had systemic ALCL (12.1%) and 22 had primary cutaneous ALCL (1.7%). Patients with anaplastic lymphoma kinase-positive (ALK(+)) ALCL had a superior outcome compared with those with ALK(-) ALCL (5-year failure-free survival [FFS], 60% vs 36%; P = .015; 5-year overall survival [OS], 70% vs 49%; P = .016). However, contrary to prior reports, the 5-year FFS (36% vs 20%; P = .012) and OS (49% vs 32%; P = .032) were superior for ALK(-) ALCL compared with PTCL, not otherwise specified (PTCL-NOS). Patients with primary cutaneous ALCL had a very favorable 5-year OS (90%), but with a propensity to relapse (5-year FFS, 55%). In summary, ALK(-) ALCL should continue to be separated from both ALK(+) ALCL and PTCL-NOS. Although the prognosis of ALK(-) ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course.

US$19.90

PMID: 18385450

DOI: 10.1182/blood-2008-01-134270


Other references

Baruch, G.K.; Barnett, R.C., 1986: Consequences of fathers' participation in family work: parents' role strain and well-being. The relation of fathers' participation in family work (child care and home chores) to parents' role strain and well-being was examined in an interview study of 160 Caucasian middle-class fathers and mothers of kindergarten and fourth-gra...

Sato, A.; Sato, Y.; Suzuki, H., 1985: Aging effects on conduction velocities of myelinated and unmyelinated fibers of peripheral nerves. Conduction velocities of myelinated and unmyelinated fibers of cutaneous sural (SU), muscular gastrocnemius soleus (GS) and parasympathetic vagus nerves were measured in Wistar rats, ranging in age from 28 to 920 days. The maximum conduction veloc...

Bolhar Robert; Kamber Balz S.; Collerson Kenneth D., 2007: U-Th-Pb fractionation in Archaean lower continental crust; implications for terrestrial Pb isotope systematics. Pb isotopic compositions are reported for leached feldspars and whole rock samples of felsic to ultramafic, amphibolite to granulite facies xenoliths from the Bearpaw Mountains in the northern Wyoming Craton, Montana, USA. Two-point dates obtained...

Wang, S.; Liu, J.; Liu, Q.; Ying, L.; Liu, X.; Zheng, H.; Liang, D., 2016: Iterative feature refinement for accurate undersampled MR image reconstruction. Accelerating MR scan is of great significance for clinical, research and advanced applications, and one main effort to achieve this is the utilization of compressed sensing (CS) theory. Nevertheless, the existing CSMRI approaches still have limita...

Ashman, PU., 1973: The effects of a Trypanosoma gambiense infection on some photoperiodic responses of Microtus montanus. Dissertation Abstr lnt, 33B8: 4031

Ferrero, S.; Grados-Torrez, R.Enrique.; Leivar, P.; Antolín-Llovera, M.; López-Iglesias, C.; Cortadellas, N.; Ferrer, J.Carles.; Campos, N., 2016: Proliferation and Morphogenesis of the Endoplasmic Reticulum Driven by the Membrane Domain of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Plant Cells. The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis and is composed of an endoplasmic reticulum (ER)-anchoring membrane domain with low sequence similari...

Plotnikov, N.A.; Panikaravskiĭ, V.V.; Genkin, M.E., 1972: Mucoepidermoid tumor of the mandible. Stomatologiia 51(5): 82-83

Tantawy, A.; Thabet, H., 1996: Normal anatomy of paratracheal lymph nodes: A cadaveric study. The paratracheal lymph nodes, (syn. recurrent laryngeal nodes, latero tracheal chain) are placed along the recurrent laryngeal nerve. Study of the normal anatomy of paratracheal lymph nodes was carried out on ten fresh cadavers immediately after a...

Alam, I.; Alam, I.; Paracha, P.I.; Pawelec, G., 2013: Higher estimates of daily dietary net endogenous acid production (NEAP) in the elderly as compared to the young in a healthy, free-living elderly population of Pakistan. Dietary intake has been shown to influence the acid-base balance in human subjects; however, this phenomenon is poorly understood and rarely reported for the least well-studied segment of older people in a developing country. The aims of the prese...

Tormo, R.U.era, J.; Dominguez, E.P.rras, A., 1986: Application of palynology to the study of problems of tribal classification in the subfamily Tubiflorae (Compositae). Pollen et spores8(3-4): 329-345