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Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis

, : Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis. Archives of Surgery 142(3): 289-93; Discussion 294

Medullary thyroid cancer cells are capable of secreting carcinoembyronic antigen (CEA). An abnormal preoperative CEA level may have important implications for the management of this condition. Retrospective analysis. Tertiary referral center at a university hospital. One hundred fifty patients with a histopathologic diagnosis of medullary thyroid cancer and preoperative CEA measurements using the same assay. Main Outcome Measure We used univariate and multivariate analyses to quantify the relationship between preoperative CEA level and tumor progression. On multivariate analysis, abnormal preoperative CEA levels were significantly associated with the initial operation rather than reoperation, larger primary tumors, positive lymph nodes, and distant metastasis. When analyses were limited to the 54 patients with increased CEA levels before the initial operation, there was a respective significant association between successive CEA levels (4.7-10.0, 10.1-30.0, 30.1-100.0, and >100.0 ng/mL) and lymph node metastases (>10 positive nodes: 0%, 9%, 53%, and 69% [P<.001]), involvement of cervical lymph node compartments (central: 33%, 36%, 73%, and 93% [P=.002]; lateral [ipsilateral]: 20%, 27%, 67%, and 88% [P=.001]; and lateral [contralateral]: 22%, 10%, 36%, and 73% [P=.008]), and distant metastasis (0%, 27%, 13%, and 75% [P<.001]). When CEA levels exceeded 30.0 ng/mL, surgical cure was exceptional. In medullary thyroid cancer, an abnormal CEA level heralds advanced disease. Carcinoembryonic antigen levels greater than 30.0 ng/mL indicate central and lateral (ipsilateral) lymph node metastases, whereas CEA levels greater than 100.0 ng/mL signify lateral (contralateral) lymph node metastases and distant metastasis.


PMID: 17372055

DOI: 10.1001/archsurg.142.3.289

Other references

Praprotnik, M.; Janezic, D., 2002: The split integration symplectic method. Cellular & Molecular Biology Letters 7(1): 147-148

Stark, J.S.; Kim, S.L.; Oliver, J.S., 2015: Anthropogenic disturbance and biodiversity of marine benthic communities in Antarctica: a regional comparison. The impacts of two Antarctic stations in different regions, on marine sediment macrofaunal communities were compared: McMurdo, a very large station in the Ross Sea; and Casey, a more typical small station in East Antarctica. Community structure an...

Ranalli, M., E.; Mercuri, O., A., 1995: The conidial state of Selinia pulchra (Ascomycotina, Hypocreales). The anamorph of Selinia pulchra, isolated from cow dung, is described and illustrated, it is a Tubercularia-like conidial form. The entire life cycle from conidium to ascospore- was reconstructed.

Hsieh, H-Fen.; Wang, H-Hung.; Shen, S-Hua.; Li, Y-Chi., 2017: Predictors of depressive symptoms among psychiatric nurses who suffered from workplace violence. We examined the possible factors that contributed to or prevented developing depressive symptoms among psychiatric nurses who suffered from workplace violence under Hill's ABC-X Model. Workplace violence-related depressive symptoms are some o...

Morini G., 1989: Potentiating effect of cimetidine on sulglycotide induced gastric mucosal protection in rat. The effects of sulglycotide, alone or combined with cimetidine, have been investigated on mucosal lesions induced in rats by pylorus ligation. In the same animals, the measurement of acid and pepsin output and of soluble and barrier mucus has been...

Becker, C.; Rohrer, H., 1972: Professor Dr. dietrich Matthias 60 years old. Archiv fur experimentelle Veterinarmedizin: 6 (4) 553-558

Toffolo G.; Cobelli C.; Avogaro A.; Bier D.M., 1988: The stable label ivgtt insulin sensitivity and glucose effectiveness from minimal models. Diabetologia 31(7): 550A

Bucher, U., 1966: Dental surgery in patients taking anticoagulants. Schweizerische Monatsschrift für Zahnheilkunde 76(9): 776-786

Brayton, R.; Mooney, H.A., 1966: Population Variability Of Cercocarpus In The White Mountains Of California As Related To Habitat. Evolution; International Journal of Organic Evolution 20(3): 383-391

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