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Acute, sublethal cyanide poisoning in mice is ameliorated by nitrite alone: complications arising from concomitant administration of nitrite and thiosulfate as an antidotal combination


, : Acute, sublethal cyanide poisoning in mice is ameliorated by nitrite alone: complications arising from concomitant administration of nitrite and thiosulfate as an antidotal combination. Chemical Research in Toxicology 24(7): 1104-1112

Sodium nitrite alone is shown to ameliorate sublethal cyanide toxicity in mice when given from ∼1 h before until 20 min after the toxic dose as demonstrated by the recovery of righting ability. An optimum dose (12 mg/kg) was determined to significantly relieve cyanide toxicity (5.0 mg/kg) when administered to mice intraperitoneally. Nitrite so administered was shown to rapidly produce NO in the bloodsteam as judged by the dose-dependent appearance of EPR signals attributable to nitrosylhemoglobin and methemoglobin. It is argued that antagonism of cyanide inhibition of cytochrome c oxidase by NO is the crucial antidotal activity rather than the methemoglobin-forming action of nitrite. Concomitant addition of sodium thiosulfate to nitrite-treated blood resulted in the detection of sulfidomethemoblobin by EPR spectroscopy. Sulfide is a product of thiosulfate hydrolysis and, like cyanide, is known to be a potent inhibitor of cytochrome c oxidase, the effects of the two inhibitors being essentially additive under standard assay conditions rather than dominated by either one. The findings afford a plausible explanation for an observed detrimental effect in mice associated with the use of the standard nitrite-thiosulfate combination therapy at sublethal levels of cyanide intoxication.

US$19.90

PMID: 21534623

DOI: 10.1021/tx2001042


Other references

Jacobs, D.M.; Ard, M.Colin.; Salmon, D.P.; Galasko, D.R.; Bondi, M.W.; Edland, S.D., 2017: Potential implications of practice effects in Alzheimer's disease prevention trials. Practice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of practice o...

Clery, R.A.; Cason, J.R.L.; Zelenay, V., 2016: Constituents of Cypriol Oil (Cyperus scariosus R.Br.): N-Containing Molecules and Key Aroma Components. Cypriol oil, the essential oil from Cyperus scariosus R.Br., has been investigated to reveal minor nitrogen-containing molecules and minor components responsible for the odor. A total of 21 nitrogenous components are reported, of which epi-guaipyr...

Han, B.H.; Kim, S.H.; Cho, H.D.k; Cho, M.G.; Bae, T.J.n, 1997: A study on the rapid processing of hydrolyzed anchovy paste and its quality stability. A study on the processing method of anchovy hydrolysate paste (AHP) was carried out to improve the sensory quality of salted and fermented fish. Homogenized whole anchovy was hydrolyzed using commercial proteases, Complex enzyme-2000 (CE, Pacific...

Anonymous, 1971: Optic effects during treatment with hydroxyqinolines. Tidsskrift for den Norske Laegeforening 91(25): 1829-1829

Esen, A.Metin.; Barutcu, I.; Karaca, S.; Kaya, D.; Kulac, M.; Esen, O.; Karakaya, O.; Melek, M.; Onrat, E.; Celik, A.; Kilit, C., 2005: Peripheral vascular endothelial function in essential hyperhidrosis. Background Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity and the aim of the present study was to determine endothelium-dependent vasodilator function in patients with this condition.Me...

Morrison, D.R., 1959: The treatment of carcinoma of the esophagus: a comparison of surgery and x-ray. Surgery 46: 516-520

Fisher, E.W.; Ritchie, D.; Thomson, A., 1965: Aortic Imcompetence In A Dog. Veterinary Record 77: 506-507

Derigo, H.T.; Hawley, W.O., 1966: Effect of time of rhizomatous propagation of a temperate zone bamboo on shoot growth. An experiment was designed to evaluate the influence of time of rhizomatous propagation of a temperate zone bamboo, Phyllostachys viridis, on shoot growth. Propagules (rhizomes) were dug at random from the field at approximately monthly intervals...

Schön, F.; Gierl, B.; Horazdovsky, W.; Stegbauer, B., 1986: 8 errors in dental practice as causes of body injuries. Die Quintessenz 37(8): 1419-1429

Leshchinskiĭ, L.A.; Trusov, V.V., 1973: Evaluation of renal status by radioindication methods in chronic glomerulonephritis and chronic pyelonephritis. Klinicheskaia Meditsina 51(8): 37-44