+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)

, : Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM). Journal of Hepato-Biliary-Pancreatic Surgery 15(5): 531-535

We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia. A 72-year-old Japanese man was admitted to our institution complaining of fever and abdominal pain. Abdominal computed tomography demonstrated a large tumor in the body of the pancreas, with multiple liver metastases. Both serum calcium and PTH-rP levels were elevated. No accumulation was observed on bone scan with technetium-99. The patient died of pneumonia 3 months after admission. Autopsy demonstrated that the neoplasm in the pancreas showed an abrupt histological transition from adenocarcinoma to squamous cell carcinoma. PTH-rP was identified in the primary pancreatic tumor cells by immunohistochemical examination and a reverse-transcription polymerase chain reaction (RTPCR) method. We concluded that PTH-rP was the causative factor of the HHM, based on the laboratory data, immunohistochemical examination, and messenger RNA (mRNA) expression. This is a very rare report of adenosquamous cell carcinoma of the pancreas associated with HHM.


PMID: 18836809

DOI: 10.1007/s00534-007-1258-x

Other references

Feng, Q.; Zhang, X.; Ma, X.; Yang, L., 1998: Studies on microbial factor on color change of Dunhuang Mural: II. Effect of Cladosporium sp. on color-change of red lead in the surface of Mural. The conditions isolated Cladosporium sp. from Mural of Dunhuang grotto germinated on the surface of imitated mural were as follows: 20degreeC RH 60% or 30degreeC RH 50%, which could be reached occasionally in some grottoes. Bone glue had protectiv...

Zierdt C.H.; Maclowry J.D., 1983: Evidence for transient staphylococcus epidermidis bacteremia in patients and in normal humans. Abstracts of the Annual Meeting of the American Society for Microbiology 83: D68

Connor, B., 1973: Case for diagnosis: leukocytoclastic vasculitis. Proceedings of the Royal Society of Medicine 66(5): 438-440

Brown, Gary E., 1972: The effects of septal lesions in the mongolian gerbil meriones unguiculatus. Psychonomic Science 29(5): 299-300

Borrill, P.; Adamski, N.; Uauy, C., 2016: Genomics as the key to unlocking the polyploid potential of wheat. Polyploidy has played a central role in plant genome evolution and in the formation of new species such as tetraploid pasta wheat and hexaploid bread wheat. Until recently, the high sequence conservation between homoeologous genes, together with t...

Zumpt, F., 1964: The Calliphoridae of the Madagascan region (Diptera). Part II. Miltogramminae and Sarcophaginae. Verhandlungen der Naturforschenden Gesellschaft in Basel, 75: 47-77

Albright, J.A., 2008: Ethics and constitutional government. The term ethics refers to a set of principles that govern acceptable, proper conduct. Attacks on the Constitution of the United States pose the most serious breach of ethics today. Our country was founded as a republic, not as a democracy. Our Fou...

Saoud, M.F.A.; Nahhas, FM.A.K.wari, KSR.; Ramadan, MM., 2002: Helminth parasites of fishes from the Arabian Gulf: 10. Trematodes of the genus Stephanostomum Looss, 1899 (Digenea: Acanthocolpidae Luehe, 1901), with description of Stephanostomum qatarense n. sp., and redescription of Stephanostomum triacanthi Madhavi, 1976. Rivista di Parassitologia. Agosto; 192: 87-103

D.Nicola P., 1983: Teaching of gerontology and geriatrics. Medicina Geriatrica 15(4): 153-158

Benevolenskii, V.; Vekshina, L.; Vnutskikh, I., 1977: Experiment Bioblok 2. 2. Inactivation of cells in yeast colonies under the action of heavy ions of galactic cosmic radiation. Radiobiologiia 17 (5) 789-792