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Age independent first trimester screening for Down syndrome: improvement in test performance

, : Age independent first trimester screening for Down syndrome: improvement in test performance. Prenatal Diagnosis 33(9): 884-888

The aim of this study was to compare screening performance for Down syndrome of the absolute risk (AR) method to the first trimester combined test (FCT) at different maternal ages. There was a retrospective analysis of 32,448 FCT. AR was defined as final risk divided by maternal age risk. The likelihood of receiving a true prediction was comparable between both methods in all age groups. With the AR method, two extra Down syndrome cases were detected in women <30 years, three cases were missed in women ≥36 years, and the likelihood of receiving a false prediction decreased overall (OR 0.82, CI 0.77-0.87; P < 0.0001), in women aged 36-40 years (0.45, CI 0.41-0.51; P < 0.0001), in women aged 41-45 years (0.18, CI 0.13-0.26; P < 0.0001) and increased in women aged ≤25 years (2.12, CI 1.52-2.96; P < 0.004). The AR method results in a significant decreased likelihood of receiving a false prediction with a comparable likelihood of receiving a true prediction. Thus, fewer invasive diagnostic tests will be performed. It will take away the misunderstanding about differences in screening performance for women of different ages. This might lead to a higher uptake of first trimester screening resulting in a more efficient screening policy.


PMID: 23682007

DOI: 10.1002/pd.4153

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Pandeya, R.S.; White, F.H., 1984: Delgold: a new flue-cured tobacco. The new flue-cured tobacco cv. Delgold has superior grade quality and colour, lower lamina wt., higher leaf total alkaloids (15-18%) and higher yields (10-12%) compared with cv. Virginia 115. Also, Delgold has a lower level of particulate matter a...

D.B.ldassarre, A.; Secchiero, P.; Grilli, A.; Celeghini, C.; Falcieri, E.; Zauli, G., 2000: Morphological features of apoptosis in hematopoietic cells belonging to the T-lymphoid and myeloid lineages. Taking into account that apoptosis plays a pivotal role in shaping normal hematopoiesis, morphological features of apoptosis were investigated in both primary cells and continuous cell lines committed towards the T-lymphoid and the myeloid lineage...

Sexton, A.; Drake, P.M.; Mahmood, N.; Harman, S.J.; Shattock, R.J.; Ma, J.K-C., 2005: Transgenic plant production of Cyanovirin-N, an HIV microbicide. Cyanovirin-N (CV-N) is a microbicide candidate that inactivates a wide range of HIV strains by binding to gp120. Production of CV-N, or any protein microbicide, needs to be at extremely high levels and low cost to have an impact on global health....

Knapp, S.; Amorelli, B.; Darout, E.; Ventocilla, C., C.; Goldman, L., M.; Huhn, R., A.; Minnihan, E., C., 2005: A family of mycothiol analogues. A thioglycoside aminotriol scaffold has been elaborated by acylation, reductive alkylation, sulfonation, phosphorylation, and other procedures to produce a library of 40 functionalized thioglycosides that superficially resemble the enzyme-binding...

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Mori, S.N.shizawa, N.U.hino, H.N.shimura, Y., 1977: Utilization of organic nitrogen as the sole nitrogen source for barley. Proceedings of the International Seminar on Soil Environment and Fertility Management in Intensive Agriculture: 12-617

Anonymous, 2011: Cumulative Exposure to Gamma Interferon-Dependent Chemokines CXCL9 and CXCL1 Correlates with Worse Outcome After Lung Transplant. Outcomes following lung transplant are suboptimal owing to chronic allograft failure termed bronchiolitis obliterans syndrome (BOS). Prior work in both mice and humans has shown that interferon gamma (IFNG)-induced chemokines, including CXCL9 and...

Schubert, S.; Dufke, S.; Sorsa, J.; Heesemann, J., 2004: A novel integrative and conjugative element (ICE) of Escherichia coli: The putative progenitor of the Yersinia high-pathogenicity island. Diversification of bacterial species and pathotypes is largely caused by horizontal transfer of diverse DNA elements such as plasmids, phages and genomic islands (e.g. pathogenicity islands, PAIs). A PAI called high-pathogenicity island (HPI) carr...

Budurov Kiril, 1971: Some denticulate conodonts from the European Triassic. Descriptions of three species, Lonchodina angulata n. sp., Prioniodina pronoides n. sp., Germany, Mediterranean region.

Liu, L.; Wu, X.; Fan, L.; Chen, X.; Hu, Z., 2006: Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis. A simple, rapid, and accurate method for the separation and determination of honokiol and magnolol in Magnolia officinalis and related herbal medicines was developed by combination of flow injection (FI) and capillary zone electrophoresis (CZE). T...