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Aluminum interaction with glutamate and α-ketoglutarate: a computational study


, : Aluminum interaction with glutamate and α-ketoglutarate: a computational study. Journal of Physical Chemistry. B 118(24): 6680-6686

Aluminum, although a nonessential element in the human body, has been found to be involved in a variety of diseases. Thus, it has recently been reported that aluminum interferes with the metabolic tricarboxylic acid cycle, in which α-ketoglutarate (α-KG) is involved. α-KG is transformed to glutamate (or vice versa) by glutamate dehydrogenase (GDH). Al(III) inhibits the normal function of GDH, and it was speculated that the reason for this inhibition is triggered by the Al(III)-assisted tautomerization of α-KG from keto to enol. In the present study, we investigate the interaction of both tautomers of α-KG with Al(III) as well the complexation of glutamate to the metal. The results confirm that Al(III) indeed displaces the tautomerization reaction and favors the enol form of α-KG by 28 kcal/mol. However, when citrate is included in the system, the stabilization of the enol tautomer decreases, as this tautomer is only 1.5 kcal/mol more stable than the keto form of α-KG. Finally, possible routes for the complexation of these molecules to Al(III) in a biological environment are discussed; we propose that the ternary complexes formed by Al(III), citrate, and α-KG or glutamate can be the more likely species.

US$19.90

PMID: 24874214

DOI: 10.1021/jp502724w


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Shao YingMei; Wen Hao, 1998: Experimental study on treatment of echinococcosis granulosus in liver and abdomen with liposome-entrapped albendazole. This study investigated the effect of liposomal albendazole (L-ABZ) or free albendazole on experimental Echinococcus granulosus infection and the effect of co-administration with cimetidine (CMD). Experimental mice were divided into 4 testing grou...

Dupont, A., 1971: Lingual metastasis from a malignant melanoma of the foot appearing 9 years after exeresis of the latter. Bulletin de la Societe Francaise de Dermatologie et de Syphiligraphie 78(1): 69-69

Garry, R.C.; Wood, H.O., 2014: Dietary requirements in human pregnancy and lactation; a review of recent work. Nutrition Abstracts and Reviews 15: 591-621

Moote, W.; Kim, H., 2011: Allergen-specific immunotherapy. Allergen-specific immunotherapy is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. However, despite its proven efficacy in these...

Ginsburg, S.; Regehr, G.; Lingard, L., 2003: The disavowed curriculum: understanding student's reasoning in professionally challenging situations. Understanding students' perceptions of and responses to lapses in professionalism is important to shaping students' professional development. Utilize realistic, standardized professional dilemmas to obtain insight into students' rea...

Jordan, T.D., 1972: Legal responsibilities of the nurse--today and tomorrow. 1. Aarn News Letter 28(6): 3 Passim-3 Passim

Houry, S.; Lechaux, J.P.; Huguier, M.; Molkhou, J.M., 1987: Treatment of rectal prolapse by Delorme's operation. Rectopexy in the sacral hollow or to the promontory with synthetic material is the most efficient method of reducing and fixing a complete rectal prolapse. However, this distressing condition occurs frequently in elderly patients, often with high...

Miller, D.C.; Syamlal, M.; Mebane, D.S.; Storlie, C.; Bhattacharyya, D.; Sahinidis, N.V.; Agarwal, D.; Tong, C.; Zitney, S.E.; Sarkar, A.; Sun, X.; Sundaresan, S.; Ryan, E.; Engel, D.; Dale, C., 2014: Carbon Capture Simulation Initiative: a case study in multiscale modeling and new challenges. Advanced multiscale modeling and simulation have the potential to dramatically reduce the time and cost to develop new carbon capture technologies. The Carbon Capture Simulation Initiative is a partnership among national laboratories, industry, an...

Chang Howard H.; Jennings Marshall E.; Olona Steve, 1992: Computer simulation of river channel changes at a bridge crossing on a point bar. Pages 76-81 1992

Mathias, Me, 1972: Plants and their names. California horticultural journal: 33 (2) 45-48