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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

, : An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. American Journal of Pathology 174(6): 2023-2034

Previously, we showed that caveolin-1 (Cav-1) expression is down-regulated in human breast cancer-associated fibroblasts. However, it remains unknown whether loss of Cav-1 occurs in the breast tumor stroma in vivo. Here, we immunostained a well-annotated breast cancer tissue microarray with antibodies against Cav-1 and scored its stromal expression. An absence of stromal Cav-1 was associated with early disease recurrence, advanced tumor stage, and lymph node metastasis, resulting in a 3.6-fold reduction in progression-free survival. When tamoxifen-treated patients were selected, an absence of stromal Cav-1 was a strong predictor of poor clinical outcome, suggestive of tamoxifen resistance. Interestingly, in lymph node-positive patients, an absence of stromal Cav-1 predicted an 11.5-fold reduction in 5-year progression-free survival. Clinical outcomes among patients positive for HER2, and patients triple-negative for estrogen receptor, progesterone receptor and HER2, were also strictly dependent on stromal Cav-1 levels. When our results were adjusted for tumor and nodal staging, an absence of stromal Cav-1 remained an independent predictor of poor outcome. Thus, stromal Cav-1 expression can be used to stratify human breast cancer patients into low-risk and high-risk groups, and to predict their risk of early disease recurrence at diagnosis. Based on related mechanistic studies, we suggest that breast cancer patients lacking stromal Cav-1 might benefit from anti-angiogenic therapy in addition to standard regimens. We conclude that Cav-1 functions as a tumor suppressor in the stromal microenvironment.


PMID: 19411448

DOI: 10.2353/ajpath.2009.080873

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Asano,K.; Watanabe,M., 2008: Current research situation and new directions in valuing environmental resources. Although environmental valuation research is frequently published in many journals, there are few actual environment policies for which environmental valuation has been used other than in project evaluation. This paper considers the criticisms of...

Mayer, L.D.; Hope, M.J.; Cullis, P.R.; Janoff, A.S., 1985: Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles. It has recently been observed (Gruner, Lenk, Janoff and Ostro (1985) Biochemistry, in the press) that mechanical dispersion of dry lipid in an aqueous buffer to form multilamellar vesicle (MLV) systems does not result in equilibrium trans-membrane...

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Becker, A., 1961: On unusual tumors in the otorhinolaryngological area. Zeitschrift für Laryngologie, Rhinologie, Otologie und Ihre Grenzgebiete 40: 447-452

Hymowitz, T., 1973: Electrophoretic analysis of SBTI-A2 in the USDA soybean germplasm collection. Seeds from 1595 accessions tested all contained the major soya-bean trypsin inhibitor, SBTI-A2. The Rf 0.79 electrophoretic form of SBTI-A2 was present in 1255 introductions while the form Rf 0.75 was present in 338 introductions. A third form of...

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Higgins, J.C., 1952: Arrival dates of Fantail and Pintail Snipe in Burma. Journal of the Bombay Natural History Society, 51: 280