geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells


, : An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. Journal of Neuroscience 34(25): 8507-8518

The bHLH transcription factor Olig2 is expressed in cycling neural progenitor cells but also in terminally differentiated, myelinating oligodendrocytes. Sustained expression of Olig2 is counterintuitive because all known functions of the protein in expansion of neural progenitors and specification of oligodendrocyte progenitors are completed with the formation of mature white matter. How are the biological functions of Olig2 suppressed in terminally differentiated oligodendrocytes? In previous studies, we have shown that a triple serine motif in the amino terminus of Olig2 is phosphorylated in cycling neural progenitors but not in their differentiated progeny. We now show that phosphorylation of the triple serine motif regulates intranuclear compartmentalization of murine Olig2. Phosphorylated Olig2 is preferentially localized to a transcriptionally active "open" chromatin compartment together with coregulator proteins essential for regulation of gene expression. Unphosphorylated Olig2, as seen in mature white matter, is localized mainly within a transcriptionally inactive, chromatin fraction characterized by condensed and inaccessible DNA. Of special note is the observation that the p53 tumor suppressor protein is confined to the open chromatin fraction. Proximity ligation assays show that phosphorylation brings Olig2 within 30 nm of p53 within the open chromatin compartment. The data thus shed light on previously noted promitogenic functions of phosphorylated Olig2, which reflect, at least in part, an oppositional relationship with p53 functions.

US$19.90

PMID: 24948806

DOI: 10.1523/JNEUROSCI.0309-14.2014


Other references

Metzger, M.F.; Faruk Senan, N.A.; O'Reilly, O.M.; Lotz, J.C., 2011: Minimizing errors associated with calculating the location of the helical axis for spinal motions. One of the more common comparative tools used to quantify the motion of the vertebral joint is the orientation and position of the (finite) helical axis of motion as well as the amount of translation along, and rotation about, this axis. A survey...

Kranz Robert L.; Blacic J.D., 1986: Direct hydraulic diffusivity measurements on laboratory rock samples. Eos, Transactions, American Geophysical Union 67(16): 381

Bernazzani, P.; Chapados, C.; Delmas, G., 2001: Phase change in amylose-water mixtures as seen by Fourier transform infrared. The phase content of amylose-water mixtures (0.7/0.3 w/w) has been analyzed by transmission Fourier transform infrared (FTIR) spectroscopy in the 1175-950 cm(-1) region. Spectra are obtained under three different conditions: (a) as a function of t...

Ishii, T.; Yamaguchi, M.; Kametaka, M., 1983: Relation between labile body protein and dietary protein. A purified diet with 20% egg protein was given to 36 male Wistar rats weighing 300 g for 8 days after which 12 were killed and the rest given a diet with 5% egg protein for 2 days. Then 12 were killed and the remainder had the diet with 20% egg pr...

White, J.M.; Cornish, F.; Kerr, S., 2015: Front-line perspectives on 'joined-up' working relationships: a qualitative study of social prescribing in the west of Scotland. NlmCategory="UNASSIGNED">Cross-sector collaboration has been promoted by government policies in the United Kingdom and many western welfare states for decades. Literature on joint working has focused predominantly on the strategic lev...

Hong, J.Eun.; Hong, K-Jong.; Choi, W.Young.; Lee, W-Ja.; Choi, Y.Hwa.; Jeong, C-Hyeon.; Cho, K-Il., 2015: Ebola hemorrhagic Fever and the current state of vaccine development. Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with...

Joshi,P.K.; Jha,A.K.; Wani,S.P.; Sreedevi,T.K.; Shaheen,F.A., 2008: Impact of watershed program and conditions for success a meta-analysis approach. Development of rain-fed areas in India is one of the prime concerns of the Government as 60 per cent of agriculture is rain-fed. Rain-fed areas are the hot-spots of poverty, water scarcity, malnutrition and are prone to severe land degradation. Wa...

Harkrider David; Press Frank, 1967: The krakatoa air-sea waves-an example of pulse propagation in coupled systems. The Geophysical Journal of the Royal Astronomical Society 13: 149-159

Newbold, S.K., 2017: What Practicing Nurses Need to Know About Health Information Technology in Order to Practice Today: Continuing Education and Certification. This chapter focuses on informatics and information management continuing education for all practicing nurses, as well as certification for informatics nurse specialists.

Fidler, D.C., 1995: Videos of Sigmund Freud's Most Famous Cases. Academic Psychiatry 19(2): 123-124