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An antimycobacterial cyclodepsipeptide from the entomopathogenic fungus Ophiocordyceps communis BCC 16475

, : An antimycobacterial cyclodepsipeptide from the entomopathogenic fungus Ophiocordyceps communis BCC 16475. Journal of Natural Products 73(1): 75-78

A novel cyclodepsipeptide, cordycommunin (1), and two dihydroisocoumarins (2 and 3) were isolated from the insect pathogenic fungus Ophiocordyceps communis BCC 16475. The absolute configurations of the amino acid residues of 1 were addressed by application of Marfey's method. Cordycommunin (1) showed growth inhibition of Mycobacterium tuberculosis H37Ra with an MIC value of 15 microM. This compound also exhibited weak cytotoxicity to KB cells with an IC50 of 45 microM, while it was inactive against BC, NCI-H187, and Vero cell lines at a concentration of 88 microM (50 microg/mL).


PMID: 20028029

DOI: 10.1021/np900520b

Other references

Pruszewicz, A., 1999: Report from the academic workshop on: "New objective examination methods in audiology and otoneurology". Warsaw, September 24-26, 1998. Otolaryngologia Polska 53(3): 361-362

Gibbs, J.N.; Lipscombe, M.A.; Peace, A.J., 1999: The impact of Phytophthora disease on riparian populations of common alder (Alnus glutinosa) in southern Britain. In 1994 a survey was established to obtain information on Phytophthora disease of common alder (A. glutinosa) on the riverbanks of southern England and east Wales. Within an area of 70 000 kmsuperscript 2 63 observation plots were set up on stretc...

Macurik, K.M.; Kohn, J.M.; Kavanaugh, E., 1978: An alternative target in the study of schedule induced aggression in pigeons. A live protected target controlled higher rates of attack over all subjects than did a mirror or stuffed targets, regardless of the FR [fixed ratio] level in effect when the live target was introduced. This technique permitted the presentation of...

Martinez, M.I., 2000: The neuroendocrine and endocrine systems, and the regulation of reproduction in Scarabaeoidea (Coleoptera). To date, nearly 30 000 species of Scarabaeidae beetles are known worldwide; however, only in 53, 47 and 3 species have the pars intercerebralis, corpora cardiaca and corpora allata structures, respectively, been described. Control of reproduction...

Overstreet William C.; Bell Henry I.I., 1962: A neglected geologic map of South Carolina. A multicolor geologic map of the State of South Carolina at a scale of 1 in. to 10 mi. was published in 1883 by Harry Hammond in a volume titled "South Carolina. Resources and Population, Institutions and Industries. " The map is largely...

Grussu, M.; Poddesu, G., 1990: Considerazioni sulla presenza dell'airone Schistaceo, Egretta gularis, in Europa i sui problemi dell'dentificazione in natura. Rivista Italiana di Ornitologia. 1989 ; 593-4: 172-182

Egashira, T.; Inoue, T.; Shirai, Y.; Iwata, K.; Honma, J.; Koyama, T., 2012: Adjunctive gabapentin for treatment-resistant insomnia of bipolar disorder: a case report. We report a case with bipolar II disorder having mixed features, in which refractory insomnia persisted. We diagnosed his case as mixed depression with mood fluctuations because increased impulsivity and buying sprees became remarkable, with dimin...

Naef, A., 1923: Kritische Biologie und ihre Gliedurung. Ueber systematische Morphologie und ihre Bedeutung fur die Wissenschaft und Lehre vom Leben. Vierteljahrsch Ges. Zurich: 329-334 387-397

Stephens, Pl, 1995: Improved recovery through green finger joining--the Greenweld process. Proceedings 6th) 17-22

Hargett, David, 1992: A laboratory for quality control of pearls. Bulletin de l'Institut Oceanographique (Monaco) 0(SPEC ISSUE 8): 127-132