+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Analysis of VDR gene polymorphism Fok1 in infertile women with endometriosis

, : Analysis of VDR gene polymorphism Fok1 in infertile women with endometriosis. Revista Brasileira de Ginecologia E Obstetricia 33(2): 65-69

to evaluate the frequency of VDR gene polymorphism Fok1 in infertile women with endometriosis and Control and its relation to the disease. a case-control study that included 147 infertile women with endometriosis and 154 fertile women without endometriosis as Control. Fok1 polymorphism (rs10735810, T2C), which promotes a T/C exchange in exon 2 of the VDR gene, was identified by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), that involves the combination of amplification by PCR and digestion with restriction endonuclease. The χ2 test was used to compare allele and genotype frequencies between groups. All p-values were two-tailed and a p-value < 0.05 was considered statistically significant. the TT, TC and CC genotype frequencies of VDR Fok1 polymorphism were 44.2%, 46.9% and 8.9% in infertile women with endometriosis and 41.6%, 50% and 8.4% in the Control Group. No significant difference was found (p=0.8), even when the patients were subdivided according to the stage of endometriosis (p=0.3 for minimal and mild endometriosis and p=0.2 for moderate and severe endometriosis). Alleles T and C were present, respectively, in 67.6% and 32.3% of infertile women with endometriosis (p=0.8), in 63.5% and 36.5% of women with minimal/mild endometriosis (p=0.5), in 72.5% and 27.5% of women with moderate/severe endometriosis (p=0.2), and in 66.6% and 33.4% of the Control Group. No statistically significant difference was found among any groups and the Control. the results suggest that VDR gene polymorphism Fok1 does not confer genetic susceptibility to endometriosis-associated infertility in the Brazilian population.


PMID: 21779647

Other references

Finardi; Flepp; Parisi; Holzner; Badii; Brun, 1992: Topological and metric analysis of heteroclinic crisis in laser chaos. Physical Review Letters 68(20): 2989-2991

Grot, E., 1952: The 50th anniversary of the Society for Fight against Venereal Diseases. Zeitschrift für Haut- und Geschlechtskrankheiten 13(9): 259-260

Slama, O., 1971: The radio-communication system in the Krtiny training forest enterprise. A detailed description [cf. FA 31, 4641].

Araneda, S.; Magoul, R.; Calas, A., 1989: Tracing specific transmitter pathways in the rat CNS: combination of [3H]serotonin retrograde labelling with immunocytochemical detection of endogenous transmitters. Selective retrograde labelling with [3H]serotonin ([3H]5-HT) can be used to identify serotonergic cell bodies after specific [3H]5-HT uptake by the corresponding nerve terminals. In the present study, we demonstrate that autoradiography of this [3...

Sherniakov, M.A., 1969: The regimental medical station in an attack operation. Voenno-Meditsinskii Zhurnal 9: 13-15

Smith, A.R., 2005: Floristics in the 21st century: Balancing user-needs and phylogenetic information. The status of floristic work on pteridophytes around the world is reviewed. Relatively modem floras exist for most temperate and Mediterranean areas, including Europe, the former Soviet Union, North America north of Mexico, Chile, South Africa, an...

Preininger, V.; Novak, J.; Simanek, V.; Santavy, F., 1978: Isolation and chemistry of the alkaloids from plants of the papaveraceae part 73. From plants of the species Corydalis lutea (L.) DC., cultivated in the Botanical Garden in Olomouc (USSR), a mixture of alkaloids (0.96%) was isolated. It contained the major alkaloids coptisine and (+)-isocorydine together with adlumidiceine, adl...

Aref'eva, Z.S.; Zav'ialov, A.P.; Nazarov, V.A.; Rudnitskaia, E.I.; Khriashcheva, L.A., 1979: Computer analysis of the effect on rat liver of alpha particles from curium-244. Radiobiologiia 19(1): 91-95

Matikainen, M.P.; Pukkala, E.; Ikonen, T.; Tammela, T.L.J.; Sankila, R.; Kallioniemi, O.P., 2001: Incidence of secondary cancers in 37 783 primary prostate cancer patients. Scandinavian Journal of Urology & Nephrology 35(Suppl 208): 23-24

Gallo, S., 1987: Endoscopic placement of nasoenteral feeding tubes. Gastrointestinal Endoscopy 33(2): 126-127