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Analysis of factors that determine weight gain during smoking cessation therapy


, : Analysis of factors that determine weight gain during smoking cessation therapy. Plos One 8(8): E72010-E72010

Cigarette smokers are generally known to gain weight after quitting smoking, and such weight gain is thought to contribute to the worsening of glucose tolerance. While smoking cessation therapy such as nicotine replacement is useful to minimize post-cessation weight gain, substantial gain occurs even during the therapy. The purpose of the present study was to identify factors associated with weight gain during smoking cessation therapy. We evaluated 186 patients(132 males and 54 females)who visited our outpatient clinic for smoking cessation, and successfully achieved smoking abstinence. We performed gender-adjusted regression analysis for the rate of BMI increase from the beginning of cessation to 3 months after initiation. Furthermore, we performed multivariate analysis to investigate factors that determine the BMI increase after smoking cessation. The mean BMI significantly (p<0.0001) increased from 23.5 ± 3.6 kg/m(2) at the initial consultation to 23.9 ± 3.8 kg/m(2) at 3 months after the start of therapy. There was no significant difference in the extent of BMI increase between nicotine patch and varenicline therapy groups. Factors significantly correlated with the %BMI increase at 3 months after the start of therapy were triglyceride (p = 0.0006, βa = 0.260), high-density lipoprotein cholesterol (p = 0.0386, βa = -0.168), daily cigarette consumption (p = 0.0385, βa = 0.154), and the Fagerström Test for Nicotine Dependence (FTND) score (p = 0.0060, βa = 0.203). Stepwise multivariate analysis demonstrated that triglyceride and the FTND score were the factors determining the post-cessation BMI increase and that the FTND score was the strongest one. The present study demonstrated that smokers with a high FTND score are more likely to gain weight during smoking cessation therapy. Thus, smokers with a high nicotine dependency may require intervention against weight gain in the cessation clinic.

US$19.90

PMID: 23991026

DOI: 10.1371/journal.pone.0072010


Other references

Unsicker K., 1985: Embryologic development of rat adrenal medulla in transplants to the anterior chamber of the eye. The morphological development and plasticity of embryonic and postnatal rat adrenal medullary cells were studied in homologous adrenal grafts to the anterior chamber of the eye. The eyes of recipient rats were adrenergically denervated 10 days pri...

McGarry, J.D.; Woeltje, K.F.; Kuwajima, M.; Foster, D.W., 1989: Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes/Metabolism Reviews 5(3): 271-284

Lin, S-Yu.; Chen, Y-Yun.; Fan, Y-Yun.; Lin, C-Wei.; Chen, S-Tsung.; Wang, A.H-J.; Khoo, K-Hooi., 2008: Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics. Inbred BALB/c mouse implanted with murine tumors serves as an attractive model system for the studies of cancer biology in immuno-competent individuals. It is anticipated that tumor progression would induce notable pathophysiological consequences,...

Bechman, K.; Gopalan, D.; Nihoyannopoulos, P.; Mason, J.C., 2017: A cohort study reveals myocarditis to be a rare and life-threatening presentation of large vessel vasculitis. The predominant forms of adult large vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu arteritis (TA). Cardiac involvement in LVV is a cause of morbidity and mortality, particularly in TA. Cardiac failure is most commonly seconda...

Mogensen, S.C.; Dishon, T., 1983: Rapid detection of herpes simplex virus and varicella-zoster virus in clinical specimens by the use of Staphylococcus aureus rich in protein A. Herpes simplex virus (HSV) type 1 and type 2 and varicella-zoster virus (VZV) were detected in cytospin preparations from clinical material by using specific antisera and Staphylococcus aureus, Cowan 1 strain, rich in protein A (SRA). Virus was is...

Bulman, J.; Nan, A.; Markland, M.Hulm.; Al-Safi, W.; Leeson, S., 2003: A questionnaire study of women's views regarding the effectiveness of serum Down screening in north west Wales. Questionnaires were circulated to 300 women awaiting mid-trimester anomaly scanning in north west Wales to determine women's views of the adequacy of counselling, availability of pretest scanning, method of receiving test results and whether...

Krstic M.K., 1972: The effect of changing concentration of the same dose of some ganglionic stimulants on the ganglionic response to these drugs. Iugoslavica Physiologica Pharmacologica Acta 8(1): 159-161

Ziv, G.; Sulman, F.G., 1972: Binding of antibiotics to bovine serum and ovine serum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2(3): 206-213

Diniz, D.G.; Foro, César.A.R.; Rego, C.M.D.; Gloria, D.A.; de Oliveira, F.R.R.; Paes, J.M.P.; de Sousa, A.A.; Tokuhashi, T.P.; Trindade, L.S.; Turiel, Míra.C.P.; Vasconcelos, E.G.R.; Torres, Jão.B.; Cunnigham, C.; Perry, V.H.; Vasconcelos, P.F.da.Costa.; Diniz, C.W.P., 2010: Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes. Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed...

Tai, A.S.; Sidjabat, H.E.; Kidd, T.J.; Whiley, D.M.; Paterson, D.L.; Bell, S.C., 2015: Evaluation of phenotypic screening tests for carbapenemase production in Pseudomonas aeruginosa from patients with cystic fibrosis. Carbapenemase phenotypic tests (inhibitor-based, modified Hodge and Carba NP) for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF) were evaluated with PCR as a reference assay. Except for Carba NP, all methods demonstrated h...