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Analysis of safety data in children after receiving two doses of ProQuad® (MMRV)

, : Analysis of safety data in children after receiving two doses of ProQuad® (MMRV). Vaccine 32(52): 7154-7160

In randomized clinical studies, over 11,800 children, 12 months to 6 years of age, were administered ProQuad(®), a combination measles, mumps, rubella, and varicella vaccine (MMRV). This paper describes the safety following a 2-dose regimen of MMRV administered to children in the second year of life. Safety data from five clinical studies were combined for all children who were scheduled to receive two doses of MMRV ∼3-6 months apart. All vaccinated children were followed for safety following each dose of MMRV. Of 3112 children who received a first dose of MMRV, 2780 (89.3%) received a second dose of MMRV. Overall, 70.5% and 57.7% of children reported ≥1 adverse experiences following first and second doses of MMRV, respectively. Injection-site redness was statistically significantly higher postdose 2 than postdose 1, while injection-site pain/tenderness was statistically significantly higher postdose 1 compared to postdose 2. Rashes were statistically significantly lower postdose 2 compared to postdose 1. Ten febrile seizures (8 postdose 1, 2 postdose 2) were reported following MMRV vaccination. The incidence of febrile seizures postdose 1 of MMRV was 0.26% (8/3019) compared to 0.07% (2/2695) postdose 2 of MMRV. Administration of two doses of MMRV has an acceptable safety profile in children 12 to 23 months of age. There is a small increase in the risk of febrile seizures following the first dose of MMRV as compared to the component vaccines, but the risk for any individual child is relatively low.


PMID: 25219563

DOI: 10.1016/j.vaccine.2014.08.067

Other references

Davis G.M., 1976: Origin of Asian Hydrobiidae in time and space. Bulletin - American Malacological Union 1975: 62

Szalma, József.; Vajta, László.; Lempel, E.; Tóth, Ákos.; Jeges, Sára.; Olasz, L., 2017: Intracanal temperature changes during bone preparations close to and penetrating the inferior alveolar canal: Drills versus piezosurgery. The aim of this in vitro study was to investigate temperature increases in the inferior alveolar canal (IAC), when different bone preparation methods approximate and penetrate the IAC. In pig mandible, buccal bone removals were performed until th...

Anonymous, 1989: The dairy industry in figures. The key statistics for the Netherlands dairy industry in 1988 and earlier years are presented in 14 tables and 2 graphs.

Pandey, S.; Kushwaha, R.S.; Mehndiratta, P.; Mehndiratta, M.M., 2009: Carbimazole induced ANCA positive vasculitis. Anti-thyroid drugs, like carbimazole and propylthiouracil (PTU) are commonly prescribed for the treatment of hyperthyroidism. One should be aware of the side effects of antithyroid medications. Antineutrophil cytoplasmic antibody (ANCA)--associate...

Kowalkowski, A.K.ol, H., 1977: Profile structure of the toposequence of soils on a loess slope with fossile soil. Roczniki gleboznawcze Soil science annual: 8 (3 4) 115-127

Pozzi, M.Celli, E.; Vidal, B., 1956: Application of fluoroelectrometry to the study of lung tumors. Il Friuli Medico 11(6): 815-839

Detjen, J., 1990: Clash over experiments on animals. Washington post2, 189(189): 6

Weiss, J.; Freeborn, D.K.; Lamb, S., 1973: Use of mental health services by poverty and nonpoverty members of a prepaid group practice plan. Health Services Reports 88(7): 653-662

Goldraij, A.; Curtino, J.A., 1996: M-glycogenin, the protein moiety of Neurospora crassa proteoglycogen, is an auto- and transglucosylating enzyme. Neurospora crassa proteoglycogen was purified and its protein moiety, M-glycogenin, was released by amylolytic treatment. The released protein was capable of autoglucosylation from UDP-glucose forming glucosyl-alpha-1,4-glucosyl linkage. The kinet...

Jones E.C., 1971: Drinking behavior of food deprived rats during feeding sessions. Psychological Reports 28(3): 869-870