+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Angioedema associated with Crohn's disease: response to biologics

, : Angioedema associated with Crohn's disease: response to biologics. World Journal of Gastroenterology 18(34): 4787-4790

A 46-year-old female patient with terminal ileum Crohn's disease and ankylosing spondylitis presented with recurrent angioedema and urticaria. Investigations ruled out hereditary angioedema, and environmental or food allergen triggers. She was diagnosed with chronic idiopathic urticaria with angioedema, and was treated with a trial of intravenous immunoglobulin immunotherapy, danazol, prednisone and hydroxyzine. Due to ongoing bowel and arthritic complaints, she was started on infliximab infusions and within 2 treatments, she had complete resolution of the angioedema and urticaria, as well as of the bowel and arthritic symptoms. Unfortunately she developed allergic reactions to the infliximab and was switched to another anti-tumor necrosis factor (TNF)-α agent, adalimumab. Since then, she has had no further angioedema or urticaria, and her Crohn's disease has been quiescent. This is the first known case report of chronic idiopathic urticaria with angioedema coexistent with Crohn's disease that was successfully treated with anti-TNF-α agents.


PMID: 23002350

DOI: 10.3748/wjg.v18.i34.4787

Other references

Thirlwell, M.; Thomson, D.; Trudeau, M.; Maksymiuk, A.; Shuster, J.; Gold, P., 1994: In vitro evidence for the effects of virulizin on cytokine production. Clinical & Investigative Medicine 17(4 SUPPL ): B88

Johnson E.W.; Woods S.W.; Innis R.B., 1989: Characterization of the benzodiazepine radioligand iodine 125 ro 16 0154 potential probe for spect brain imaging. Society for Neuroscience Abstracts 15(2): 1155

Hughes, V.; Uip, D.; Reingold, A.; Hearst, N., 1996: HIV infection, vaginitis and cervical neoplasia Implications for clinical care of HIV positive women in Brazil. ELEVENTH INTERNATIONAL CONFERENCE ON AIDS Eleventh International Conference on AIDS, Vol Two One world: One hope : 275

Raisingani, D.; Meshram, G.K., 2010: Cleanliness in the Root Canal System: An Scanning Electron Microscopic Evaluation of Manual and Automated Instrumentation using 4% Sodium Hypochlorite and EDTA (Glyde File Prep)-An in vitro Study. Aim : To assess the cleaning efficacy of manual and automated instrumentation using 4% sodium hypochlorite singly and in combination with Glyde file Prep as root canal irrigant. Methodology : The study utilized 40 extracted human permanent premola...

Kreutz R., 1989: Balled position in the tree boa corallus enydris linnaeus 1758. Salamandra 25(2): 115-116

Franks, P.; Clancy, C.M., 1997: Referrals of adult patients from primary care: demographic disparities and their relationship to HMO insurance. Increasing enrollment in managed care organizations and dissatisfaction with policies to restrict direct access to specialists have intensified interest in referrals from primary care physicians to specialists. We examined the associations of demo...

Svirshchevskii E.B.; Mikhailov Y.N.; Rodionov V.V.; Priimak V.P., 1980: Use of radio cardiography in evaluation of function of the right and left sections of the heart. The feasibility of using radiocardiography during separate determination of hemodynamic indices of the right and left sections of the heart was evaluated in healthy persons and in patients with myocardial infarction. The volume of the heart was co...

Lipets, M.E., 1960: The role of prednisolone and prednisolone ointment as a factor in the treatment by stages of epidermophytosis and dyshidrosis in children Information on the 2nd conference of dermatologists and venereologists of the Kuznets Basin, 1966. Observations were made on 72 children of whom 58 were suffering from epidermophytosis and 14 from dyshidrosis. Prednisolone was given in the form of an ointment, and to some of the patients by mouth, at a dosage of 0.0025-0.005 g 2-3 times daily,...

Tyutikov, S.F., 1999: Mercury in the environment and animals in the Central Black Earth Region. The data on the mercury levels in the organs of wild ungulates and agricultural animals and in the environmental objects of the Central Black Earth Region are presented. The biogeochemical parameters of organisms were calculated. Species- and orga...

Ohkubo, M.; Nakamura, Y.; Tokunaga, K.; Sakiyama, S., 1986: Similarity between glyceraldehyde-3-phosphate dehydrogenase and a 37,000-dalton protein which is abundantly expressed in human lung cancers. Human lung cancers of all histological types contain a protein of 37,000 daltons (37K) as an abundant component. Partial sequence analysis of purified 37K revealed a strong homology with glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC