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Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses

, : Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses. Cytopathology 21(5): 311-319

The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology. FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study. Original cytological diagnoses were retrieved, smears reviewed and morphological features analysed: cellularity, smear pattern, cell morphology, contents of background. Outcome of immunocytochemistry was noted and additional reactions performed if material was available. There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid. Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory. Only two primary tumours were diagnosed as vascular. According to morphology, tumours were divided into those with predominantly epithelioid cells and those with predominantly spindle cells. Within these two groups were variations due to grade of tumour. Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas. Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice at the time of diagnosis and three times retrospectively. Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common. Very few reliable data are available concerning specificity of CD31 on cytological material.


PMID: 20105214

DOI: 10.1111/j.1365-2303.2009.00726.x

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Fairchild, J.M.; Franseen, E.K.; Goldstein, R.H., 2008: Subtle sea-level and paleotopographic controls on heterogeneity of an oolite-bearing system. Oolitic reservoirs are important hydrocarbon targets, but can be notoriously heterogeneous. Dynamic interactions between currents, minor fluctuations in sea level, and subtleties of the paleotopography appear to be major causes of heterogeneity. T...

Sidhu, R., 2016: Physical Quantitative Verification of Nonsterile Compounded Preparations: Individualized Dosage Units. United States Pharmacopeia <795> states that to ensure accuracy and completeness, the compounder shall observe the finished preparation. One such verification method described in United States Pharmacopeia <1163> is weight assessment o...

Harapanhalli, R.S.; Mclaughlin, L.W.; Howell, R.W.; Rao, D.V.; Adelstein, S.J.; Kassis, A.I., 1996: I-125/I-127-iodohoechst 33342, An iodinated bisbenzimidazole Synthesis, DNA binding and biodistribution studies. Abstracts of Papers American Chemical Society 212(1-2): MEDI 202

van Rijthoven, A.W.A.M.; Bijlsma, J.W.J.; Canninga-van Dijk, M.; Derksen, R.H.W.M.; van Roon, J.A.G., 2006: Onset of systemic lupus erythematosus after conversion of infliximab to adalimumab treatment in rheumatoid arthritis with a pre-existing anti-dsDNA antibody level. Rheumatology 45(10): 1317-1319

Takamatsu, T.; Fujita, S., 1988: Microscopic tomography by laser scanning microscopy and its three-dimensional reconstruction. We have developed a new confocal laser scanning microscope equipped with two galvanometer mirrors which swing the laser beam. With this set up we can observe large and fragile specimens. Using a focused laser beam as light source to minimize &apos...

Pulim, V.; Bienkowska, J.; Berger, B., 2007: LTHREADER: prediction of ligand-receptor interactions using localized threading. Identification of ligand-receptor interactions is important for drug design and treatment of diseases. Difficulties in detecting these interactions using high-throughput experimental techniques motivate the development of computational prediction...

Skvortsova, T.Iu.; Brodskaia, Z.L.; Rudas, M.S.; Mozhaev, S.V.; Gurchin, A.F.; Medvedev, S.V., 2005: Positron emission tomography in the diagnosis of recurrent growth of brain tumors. The authors analyzed the results of 11C-methionine positron emission tomography (PET) in 101 patients with suspected recurrent brain tumor. The diagnosis was confirmed in 72 patients. The increased 11C-methionine uptake in the initial tumor area i...

Chomyszyn-Gajewska, M.; Darczuk, D.; Gałecka-Wanatowicz, D.; Cabała, A., 2008: Influence of smoking on incidence and progression of periodontal disease. Review of the literature. On the basis of available literature, presented is the influence of smoking on incidence and progression of peridontal disease. During the process of smoking; more than 400 destructive substances along with nicotine are excreted. Their effects on...

During, H., 1979: Effects of air and soil humidity on vegetative growth and water relationships of grapevines. Vitis 18(3): 211-220

Okhotnikov, Vi, 1975: The preparation Virin-Ensh for controlling the Porthetria dispar. Lesnoe khoziaistvo: 8 87-88