+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Annexin A8 regulates late endosome organization and function

, : Annexin A8 regulates late endosome organization and function. Molecular Biology of the Cell 19(12): 5267-5278

Different classes of endosomes exhibit a characteristic intracellular steady-state distribution governed by interactions with the cytoskeleton. Late endosomes, organelles of the degradative lysosomal route, seem to require associated actin filaments for proper localization and function. We show here that the F-actin and phospholipid binding protein annexin A8 is associated specifically with late endosomes. Altering intracellular annexin A8 levels drastically affected the morphology and intracellular distribution of late endosomes. Trafficking through the degradative pathway was delayed in the absence of annexin A8, resulting in attenuated ligand-induced degradation of the epidermal growth factor receptor and prolonged epidermal growth factor-induced activation of mitogen-activated protein kinase. Depletion of annexin A8 reduced the association of late endosomal membranes with actin filaments. These results indicate that the defective cargo transport through the late endocytic pathway and the imbalanced signaling of activated receptors observed in the absence of annexin A8 results from the disturbed association of late endosomal membranes with the actin network, resulting in impaired actin-based late endosome motility.


PMID: 18923148

DOI: 10.1091/mbc.E08-04-0383

Other references

Labbé, V.; Hafiani, E.Mahdi., 2015: Echocardiographic Air Bubbles. Early Sign of Intestinal Pneumatosis. American Journal of Respiratory and Critical Care Medicine 192(4): E44-E44

Ingar, C., 2008: Midwifery & birthing: women in Peru. Midwifery Today With International Midwife: 51, 67-8

Reed Thomas B.I.V.; Tucholke Brian E., 1991: Geologic visualization of the Kane fracture zone; interactive processing of side-scan and bathymetric data. Eos, Transactions, American Geophysical Union 72(17): 266

Simon Sylvestre G., 1969: Soluble sulfate contents of soils. Annales Agronomiques (Paris) 20(4): 435-447

Toliver-Kinsky, T., E.; Cui, W.; Murphey, E., D.; Lin, C.; Sherwood, E., R., 2005: Enhancement of dendritic cell production by Fms-like tyrosine kinase-3 ligand increases the resistance of mice to a burn wound infection. Fms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine that stimulates the production of dendritic cells. This study evaluated the ability of Flt3L-enhanced dendritic cell production to increase the resistance of mice to a burn wound...

Steven, J.M., 2010: Congenital heart disease and anesthesia-related cardiac arrest: connecting the dots. Anesthesia and Analgesia 110(5): 1255-1256

Anonymous, 1989: Act No. 89-475 of 10 July 1989 relating to the accomodation of the elderly and handicapped adults in the homes of individuals for payment. This French Act sets forth rules on the accommodation of the elderly and handicapped adults in the homes of individuals. It provides that such individuals must receive the approval of the president of the local general council, which is to set spe...

Mizuta, I.; Yamada, E.; Ikeda, S., 1985: Nursing of patients with head injuries at admission--practice of nursing at patients' arrival. Nursing Technique 31(15): 1993-1997

Gasser, E., 1942: Changes in butter during storage. This is a review article. Rancidity, tallowiness and fishiness are discussed, together with the possibilities of prevention.

Zaccari, F.; Galietta, G., 2015: α-Carotene and β-Carotene Content in Raw and Cooked Pulp of Three Mature Stage Winter Squash "Type Butternut". Winter squash "type butternut" is harvested in physiological ripening for better commercial distribution, when sensory and/or nutritional quality is not optimum for consumption. The objective of this study was to quantify the content of...