+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate

, : Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate. Bioorganic & Medicinal Chemistry Letters 21(23): 6996-7000

We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (-)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcus aureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity.


PMID: 22030031

DOI: 10.1016/j.bmcl.2011.09.116

Other references

Peng, J.L.n; Cao,; Fu,, 2007: Phenotypic variation in Chinese catfish (Silurus asotus Linnaeus). The head length, body height, and fin length, and fin height and tail fin height linearly increase with body length in Chinese catfish. The body weight, mouth width and tail fin length increased exponentially with body length. The relative value o...

Haemmerle, G.; Zimmermann, R.; Strauss, J.G.; Kratky, D.; Riederer, M.; Knipping, G.; Zechner, R., 2002: Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. Hormone-sensitive lipase (HSL) is believed to play an important role in the mobilization of fatty acids from triglycerides (TG), diglycerides, and cholesteryl esters in various tissues. Because HSL-mediated lipolysis of TG in adipose tissue (AT) d...

Marshall, 1976: Transiet atrial fibrillation after minor head injury. Two patients developed transient rapid atrial fibrillation after a blow on the head. There was no evidence of neurological damage or organic heart disease on subsequent investigation. Neither patient was aware of the cardiac irregularity.

Serio, M.; Calabresi, E.; Salerno, R., 1989: Endocrine manipulation of human prostatic cancer: state of the art. Journal of ChemoTherapy 1(4 Suppl): 1227-1230

Anonymous, 1985: Comparison among different methods for the diagnosis of varicocele. World Health Organization. Three noninvasive methods for the detection of retrograde blood flow in the internal spermatic vein were evaluated in 141 men complaining of infertility in four different centers. Scrotal contact thermography using flexible strips was found to be...

Bergstrand H.; Bjornsson A.; Frick I.M.; Lundquist B.; Pauwels R.; Bazin H., 1984: Anti immuno globulin e induced histamine release from rat tissues passively sensitized in vivo with myeloma immuno globulin e differs with strain and mast cell sources. Four different strains of rats, BDII, E3, LE and OM/N, each with a low basal serum level of IgE, were examined with respect to anti-IgE- and ConA[concanavalin A]-induced release of histamine from serosal mast cells and chopped lung tissue. Tests w...

Shtepa, Is, 1980: Pollen defectiveness in genus Cousina Cass. Zametki po sistematike i geografii rastenii: 6) 64-70

Singh, A.; Sivaprasad, C.V.S., 2009: Functional interpretation of APN receptor from M.sexta using a molecular model. Insect pests are the major cause of damage to commercially important agricultural crops. The continuous application of synthetic pesticides resulted in severe insect resistance by plants. This causes irreversible damage to the environment. Bacillu...

Hassan, M.; Ibrahim, M.; Khanna, L.C., 1948: The relation of vitamin A to white cells in human blood and normal white cell counts in the Punjab. To find the response of the general defense mechanisms of the body to the threshold deficiency of vit. A, the blood level of vit. A in relation to the total number of leucocytes and their differential variation in the blood was studied in 60 norma...

Gallucci, A.R.; Martin, R.J., 2016: Misuse of prescription stimulant medication in a sample of college students: examining differences between varsity athletes and non-athletes. The misuse of prescription stimulants (MPS) has been identified as an adverse health behavior among college students. Because stimulant medication is often taken to increase focus and decrease reaction time, these substances have the potential to...