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Antidepressants and the Placebo Effect


, : Antidepressants and the Placebo Effect. Zeitschrift für Psychologie 222(3): 128-134

Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin in the brain. Indeed, their supposed effectiveness is the primary evidence for the chemical imbalance theory. But analyses of the published data and the unpublished data that were hidden by drug companies reveals that most (if not all) of the benefits are due to the placebo effect. Some antidepressants increase serotonin levels, some decrease it, and some have no effect at all on serotonin. Nevertheless, they all show the same therapeutic benefit. Even the small statistical difference between antidepressants and placebos may be an enhanced placebo effect, due to the fact that most patients and doctors in clinical trials successfully break blind. The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.

US$19.90

PMID: 25279271

DOI: 10.1027/2151-2604/a000176


Other references

Seif, E.; Balaam, L.N., 1981: Regional evaluation of wheat genotypes for grain protein level in the central west of New South Wales. The analysis of wheat protein data from 10 homozygous genotypes grown at 6 locations in 4 yr gave a heritability estimate of 50%, and another of 65% from a sub-set of genotypes of similar maturity. The 1st-order interactions, genotype .times. year...

Fanny, M-Lingoupou.; Beyam, N.; Gody, J.Chrusostome.; Zandanga, G.; Yango, F.; Manirakiza, A.; Rigouts, L.; Pierre-Audigier, C.; Gicquel, B.; Bobossi, G., 2013: Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic. Tuberculosis (TB) is a major cause of childhood morbidity and mortality in developing countries. One of the main difficulties is obtaining adequate specimens for bacteriological confirmation of the disease in children.The aim of this study is to e...

Fornasieri I.; Roeder J J.; Anderson J.R., 1991: Responses to mirror image stimulation in three species of lemurs lemur fulvus lemur macaco lemur catta. Reactions when confronted with their own reflection in a mirror were observed in three captive groups of lemurs: L. fulvus, L. macaco and L. catta. The ability of a mirror to induce social facilitation of drinking was also studied in one individua...

Dua, R.; Levy, D.L.; Li, C.M., 2002: In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase e in insect cells: purification and characterization. The Journal of Biological Chemistry 277(10): 89-96

Plotnikow, J.; W.D.ttler, 1931: Uber die Fluoreszenz verschiedener Lebewesen von Adriameer und mancher anderer Objekte. Characteristic fluorescence was observed in many organisms of the Adriatic Sea (fish, crustacea, molluscs, echinoderms), entire and in sections, when observed with the Plotnikow Luminiskop (see Abderhalden's Handb. 1930). Beetles, plant leave...

Andersen, L.P.; Norgaard, A.; Holck, S.; Blom, J.; Elsborg, L., 1996: Isolation of a Helicobacter heilmanii-like organism from the human stomach. European Journal Of Clinical Microbiology & Infectious Diseases. 15(1): 95-96

Bouilly, J.; Beau, I.; Barraud, S.; Bernard, Vérie.; Azibi, K.; Fagart, Jérôme.; Fèvre, A.; Todeschini, A.Laure.; Veitia, R.A.; Beldjord, Cérif.; Delemer, B.; Dodé, C.; Young, J.; Binart, N., 2016: Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency. Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and infertility. POI affects 1% of women before age 40 years, and several genetic causes have been reported. To date, POI has been considered a monogenic disorder. The a...

Anonymous, 1943: Ussr, agricultural organization. In a lecture on this subject Sir John Russell reviewed the systems of farming before and after the Revolution. Formerly there were 3 systems, the large estate, the small peasant farm and peasant land farmed by peasants under the village council or...

Huang, Z.; Luo, W.; Ma, L.; Yu, M.; Ren, X.; He, M.; Polen, S.; Click, K.; Garrett, B.; Lu, J.; Amine, K.; Hadad, C.; Chen, W.; Asthagiri, A.; Wu, Y., 2015: Dimeric [Mo2 S12 ](2-) Cluster: A Molecular Analogue of MoS2 Edges for Superior Hydrogen-Evolution Electrocatalysis. Proton reduction is one of the most fundamental and important reactions in nature. MoS2 edges have been identified as the active sites for hydrogen evolution reaction (HER) electrocatalysis. Designing molecular mimics of MoS2 edge sites is an attr...

Chao, R.S.; Vail, K.C., 1987: Polymorphism of 1,2-dihydro-6-neopentyl-2-oxonicotinic acid: characterization, interconversion, and quantitation. Two polymorphs of 1,2-dihydro-6-neopentyl-2-oxonicotinic acid have been characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), differential scanning calorimetry (DSC), and thermal (hot-stage) microscopy (HSM). In batch-scale prepara...