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Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis


, : Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis. Autoimmunity 42(1): 1-16

A variety of clinical, epidemiological, and experimental data suggest that rheumatic heart disease and autoimmune myocarditis are not only similar in their pathogenesis, but may often be due to combined infections with coxsackie virus (CX) and streptococcus A bacteria (SA). This paper reviews the evidence for this hypothesis, provides some new experimental data supporting the hypothesis, and suggests specific experiments for testing it. While, it is well-established that the M protein of SA mimics myosin, we demonstrate using homology search tools that various CX proteins mimic actin. We further demonstrate that antibody against CX recognizes actin as an antigen, and that anti-actin antibodies recognize CX antigen. Thus, anti-CX antibodies may also target muscle. Moreover, since myosin and actin are molecularly complementary, it follows that some SA and CX proteins may be molecularly complementary. Some antibodies against these complementary proteins in SA and CX should therefore act like idiotype-antiidiotype antibodies. We show that, indeed, CX and SA antibodies precipitate each other. Thus, it is possible that combined CX-SA infections produce more severe disease by producing pairs of idiotypic antibodies that act like antiidiotypic antibodies as well, thereby, disregulating immune control and triggering an autoimmune reaction against both myosin and actin simultaneously. We predict that combinations of the appropriate actin- and myosin-like antigens from CX and SA will, therefore, be much more autoimmunogenic than antigens from CX or SA alone, and that the combination will not require use of adjuvants or self-proteins that many current protocols require. It is possible that co-infections involving CX or SA with other infectious agents may produce similarly enhanced disease.

US$19.90

PMID: 18608177

DOI: 10.1080/08916930802208540


Other references

Trotter, J.A.; Scordilis, S.P.; Margossian, S.S., 1983: Macrophages contain at least two myosins. A number of motile functions of macrophages are thought to be mediated by myosin. We have observed that myosin from rabbit alveolar macrophages is heterogeneous with respect to its 20 kDa light chain: two species of 20 kDa light chain are identifi...

Reychler, G.; Simon, A.; Lebecque, P., 2007: Cystic fibrosis: physiotherapy and the risk of cross infection. Respiratory infections play a deleterious role in the progression of patients suffering from cystic fibrosis. Cross infections and epidemics have been documented in these patients, justifying a rigorous prevention regime. This prevention regime co...

Diop A.; Guernet C.; Poignant A., 1982: Paleocene micro fauna of some drillings of west senegal remarks about the ostracoda. The Paleocene of western Senegal has a mainly benthonic microfauna; the more characteristic elements of which are the Ostracoda: Cytherella (Cytherelloidea) aff. keiji Mac Kenzie, Buntonia aff. attitogonensis Apostolescu, Soudanella laciniosa Apos...

Campana, Steven E., 1992: Measurement and interpretation of the microstructure of fish otoliths. Stevenson, D K [Editor], Campana, S E [Editor] Canadian Special Publication of Fisheries and Aquatic Sciences; Otolith microstructure examination and analysis : 59-71

Bloomfield D.A., 1979: Detection of intermittent pacemaker mal function by ambulatory monitoring. Bulletin Of The New York Academy Of Medicine: 415

Hu, W.; Howard, M.; Lukacs, G.L., 2001: Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase (PKA)-activated chloride channel that is localized to the plasma membrane and endosomal compartment. Endosomal targeting of CFTR is attributed to the...

Russo, L., 1968: Morphological and biological studies on the nematodes Heterodera schachtii and H. rostochiensis. The morphology and biology of Heterodera schachtii and H. rostochiensis are outlined. Plant hosts are listed and control measures described. Field trials in Castellamare di Stabia and Campi Flegrei, Naples, Italy, showed that early varieties of po...

Kouwaki, M.; Yokochi, M.; Kamiya, T.; Yokochi, K., 2015: Spontaneous movements in the supine position of preterm infants with intellectual disability. Spontaneous movements at 2 months of corrected age in preterm infants with intellectual disability (ID) were investigated by assessing individual motor elements separated from movements involving the entire body. Video recordings of 20 preterm inf...

Lindsey, E.A.; Brackett, C.M.; Mullikin, T.; Alcaraz, C.; Melander, C., 2012: The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors. A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies re...

Kroemer, K.H., 1964: On The Effect Of The Position Of The Keyboard On Efficiency At The Typewriter. Internationale Zeitschrift für Angewandte Physiologie, Einschliesslich Arbeitsphysiologie 20: 240-251