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Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats

, : Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats. Pakistan Journal of Pharmaceutical Sciences 27(3): 491-494

Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Physalis peruviana whole ripe fruit, water and ethanol extracts of fruit in normal as well as in carbon tetrachloride (CCl(4)) intoxicated rats. The CCl(4) treated rats showed marked elevation in liver enzymes: alanine transaminse, aspratate transaminase, alkaline phosphatase, lactate dehydrogenase and other biochemical parameters: bilirubin, creatinine and urea, thus indicating liver injury. Whereas animal treated/fed with various preparations of Physalis peruviana showed significant lowering effect (p<0.05) in the elevated levels of serum markers like ALAT, ASAT, ALP, LDH, creatinine, urea and bilirubin indicating the protection against hepatic cell damage. The water extract of Physalis peruviana showed highest activity in both rat models while ripe fruit and ethanol extract showed moderate activity compared to standard drug.


PMID: 24811807

Other references

Brusilovskii, E.A., 1962: Cicatricial deformation of the lower third of the esophagus as the result of an ulcerative process. Vestn Rentgenol I Radiol 37(5): 70

Grey, J.A.; Konstan, J.; Iantaffi, A.; Wilkerson, J.Michael.; Galos, D.; Rosser, B.R.Simon., 2016: An updated protocol to detect invalid entries in an online survey of men who have sex with men (MSM): how do valid and invalid submissions compare?. Researchers use protocols to screen for suspicious survey submissions in online studies. We evaluated how well a de-duplication and cross-validation process detected invalid entries. Data were from the Sexually Explicit Media Study, an Internet-ba...

Dennstedt F.E.; Stager C., 1982: Rapid detection of escherichia coli urinary tract infection by a new screening method. American Journal of Clinical Pathology 78(2): 275

Sunshine, A., 1980: Clinical evaluation of mild analgesics in post partum pain. 1 The design of a clinical study evaluating mild analgesics in post partum patients is dependent on the purpose of the study. Work intended to determine whether a compound has any analgesic properties, requires a different design from a study posi...

Gerth Heinrich, 1940: Die Fortsetzung der venezuelanischen Kordilleren in den Antillenbogen. The Venezuelan cordilleran ranges extend eastward through Trinidad into the Atlantic ocean. They do not form the Antilles, as believed by some. The Antilles constitute a younger structural unit.

Dubowite, Victor, 1965: Pseudo muscular dystrophy. Res Muscular Dystrophy Proc Symp 3: 57-73

Whitfield C.D.; Jefferson L.M., 1988: Chinese hamster mutant in mitochondrial nadh dehydrogenase and cytochrome c oxidase. Journal of Cell Biology 107(6 PART 3): 345A

White, I., N.H.; De-Matteis, F.; Gibbs, A., H.; Lim, C.-Kee; Wolf,; Henderson, C.; Smith, L., L., 1995: Species differences in the covalent binding of (14C)tamoxifen to liver microsomes and the forms of cytochrome P450 involved. Species differences in the NADPH-dependent covalent binding of (14C)tamoxifen to liver microsomes have been studied using preparations from humans, female F344 rats and DBA/2 mice. Protein binding has been used as an index of metabolic activation...

Visakavicius, E.; Bagdanaviciute, I.; Bitinas, A., 2011: Review of geological mapping in the Lithuanian water area. Bulletin of the Geological Society of Finland (Painettu) 83.Special Issue 1: 102

Erlinger, S., 2015: Intrahepatic cholestasis of pregnancy and hepatitis C virus: a criminal conspiracy?. Clinics and Research in Hepatology and Gastroenterology 38(3): 250-251