+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antioxidant effects of lipophilic tea polyphenols on diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in rats

, : Antioxidant effects of lipophilic tea polyphenols on diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in rats. In Vivo 28(4): 495-503

The purpose of the present study was to compare the antioxidant potential of lipophilic tea polyphenols (LTP) against the one of naturally-occurring water-soluble green tea polyphenols (GTP) in a two-stage model of diethylnitrosamine (DEN)/phenobarbital (PB)-induced hepatocarcinogenesis in Sprague-Dawley rats. GTP/LTP was given 5-times weekly by oral gavage with tea polyphenols equivalent to 0-, 40- and 400-mg/kg of body weight/day. GTP/LTP treatment was started 2 weeks prior to the initiation of DEN and continued for 30 weeks. Histopathological and electron microscopic examination of liver tissue confirmed the protective effect of LTP on DEN/PB-induced liver damage and pre-carcinogenesis. LTP treatment significantly increased total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) activity in liver tissues. Immunohistochemical detection of cellular nuclear factor erythroid-2-related factor-2 (Nrf2) and peroxiredoxin-6 (P6) indicated a down-regulation in Nrf2 and up-regulation of P6 expression in the liver of LTP-supplemented rats. The present study provides evidence for the first time, that LTP exerts significant antioxidant effects on DEN/PB-induced liver damage and hepatocarcinogenesis through elevating T-AOC levels, enhancing GSH-Px activity and inducing P6 expression in rat liver tissues.


PMID: 24982215

Other references

Jaworska, M., 1992: Biological control of Hoplocampa testudinea Klug. (Hymenoptera, Tenthredinidae). The pathogenicity of 8 species of entomogenous fungi and nematodes to 5th-instar larvae of Hoplocampa testudinea was studied in laboratory and field experiments in Poland. In the laboratory, the fungi Paecilomyces fumosoroseus, P. farinosus, Asper...

Reis P.J., 1969: The growth and composition of wool part 5 stimulation of wool growth by the abomasal administration of varying amounts of casein. Australian Journal of Biological Sciences 22(3): 745-759

Isayev V.P.; Kostyuchenkova Y.P.; Pavlenko V.V., 1985: Gas scattering halo structure above hydrocarbon pools. Geologiya Nefti i Gaza 1985(12): 44-51

Verboeket Van D.V.nne, W.P.H.G.; Westerterp, K.R., 1996: Effects of dietary fat and carbohydrate exchange on human energy metabolism. Short-term effects of low-fat (10% fat energy), mixed (30% fat energy), and high-fat (50% fat energy) diets on 24-h energy expenditure, and on its components sleeping metabolic rate, diet induced thermogenesis and energy expenditure for physical a...

Kikuchi, S.; Hasue, M.; Watanabe, M., 1978: Ischemic contracture in the lower limb. Twenty cases of ischemic contracture in the lower limb demonstrate that the age distribution may be higher than that of patients with similar lesions in the upper limbs. Non-traumatic and traumatic causes are encountered equally frequently. Pain i...

Shin, S.J.; Simpson, P.T.; D.S.lva, L.; Jayanthan, J.; Reid, L.; Lakhani, S.R.; Rosen, P.Peter., 2008: Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. Microglandular adenosis (MGA) is an uncommon, benign breast lesion that is characterized by a proliferation of small uniform, round glands lined by a single layer of epithelial cells around open lumina with haphazard infiltrative growth in fibrous...

Eulie, P.J.; Rhee, H.M.; Laughlin, M.H., 1987: Effects of [Met5]enkephalin on regional blood flow and vascular resistance in rabbits. Methionine enkephalin [( Met5]enkephalin) has different cardiovascular effects, depending on species and routes of peptide administration. In anesthetized animals [Met5]enkephalin decreases blood pressure and heart rate. The site(s) and the mechan...

Volfova, O.K.slikova, E., 1981: Production of cellulases during growth of Trichoderma viride on cellulose Microorganism used in the industrial production of enzymes. Acta biotechnologica(2): 187-189

Morris V.A.; Quesenberry L.A.; Neering I.R.; Taylor S.R., 1991: Non uniform volume changes in isolated frog skeletal muscle fibers during isometric tetani detection by high speed image intensified digital microscopy. Biophysical Journal 59(2 PART 2): 49A

Eschenbach, D.A.; Sweet, R.L., 1985: Reproductive microbiology: future perspectives. American Journal of Reproductive Immunology and Microbiology 7(1): 2-3